Cargando…
Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not
The COVID-19 pandemic has had a remarkable impact on the field of liver transplantation. Increasing evidence demonstrates a minimal risk of transmission of SARS-CoV-2 from non-lung donors who test positive for SARS-CoV-2; however, the risks of donor-derived SARS-CoV-2 from liver donors are unknown....
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Masson SAS.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951024/ https://www.ncbi.nlm.nih.gov/pubmed/38013674 http://dx.doi.org/10.1016/j.liver.2023.100146 |
_version_ | 1784893299392249856 |
---|---|
author | Kumar, Aman Abbas, Daniyal Barritt, A. Sidney Lachiewicz, Anne Fix, Oren K. Desai, Chirag S. |
author_facet | Kumar, Aman Abbas, Daniyal Barritt, A. Sidney Lachiewicz, Anne Fix, Oren K. Desai, Chirag S. |
author_sort | Kumar, Aman |
collection | PubMed |
description | The COVID-19 pandemic has had a remarkable impact on the field of liver transplantation. Increasing evidence demonstrates a minimal risk of transmission of SARS-CoV-2 from non-lung donors who test positive for SARS-CoV-2; however, the risks of donor-derived SARS-CoV-2 from liver donors are unknown. We present our experience with two cases in which a liver was transplanted successfully from a brain-dead donor with incidental SARS-CoV-2 infection. Both donors were asymptomatic SARS-CoV-2-positive with negative bronchoalveolar lavage polymerase chain reaction (BAL PCR) and mechanism of death unrelated to COVID-19. Both the recipients did well after transplant and went home with a well-functioning liver. One patient did get readmitted and was found to be SARS-CoV-2-positive; however, it was probably related to hospital exposure rather than donor-derived. SARS-CoV-2-positive donors in select cases may be used for organ donation and liver transplant is safe for recipients. |
format | Online Article Text |
id | pubmed-9951024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Author(s). Published by Elsevier Masson SAS. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99510242023-02-24 Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not Kumar, Aman Abbas, Daniyal Barritt, A. Sidney Lachiewicz, Anne Fix, Oren K. Desai, Chirag S. Journal of Liver Transplantation Case Report The COVID-19 pandemic has had a remarkable impact on the field of liver transplantation. Increasing evidence demonstrates a minimal risk of transmission of SARS-CoV-2 from non-lung donors who test positive for SARS-CoV-2; however, the risks of donor-derived SARS-CoV-2 from liver donors are unknown. We present our experience with two cases in which a liver was transplanted successfully from a brain-dead donor with incidental SARS-CoV-2 infection. Both donors were asymptomatic SARS-CoV-2-positive with negative bronchoalveolar lavage polymerase chain reaction (BAL PCR) and mechanism of death unrelated to COVID-19. Both the recipients did well after transplant and went home with a well-functioning liver. One patient did get readmitted and was found to be SARS-CoV-2-positive; however, it was probably related to hospital exposure rather than donor-derived. SARS-CoV-2-positive donors in select cases may be used for organ donation and liver transplant is safe for recipients. The Author(s). Published by Elsevier Masson SAS. 2023-05 2023-02-24 /pmc/articles/PMC9951024/ /pubmed/38013674 http://dx.doi.org/10.1016/j.liver.2023.100146 Text en © 2023 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Case Report Kumar, Aman Abbas, Daniyal Barritt, A. Sidney Lachiewicz, Anne Fix, Oren K. Desai, Chirag S. Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not |
title | Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not |
title_full | Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not |
title_fullStr | Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not |
title_full_unstemmed | Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not |
title_short | Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not |
title_sort | liver transplantation from a sars-cov-2-positive donor: a road ahead or not |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951024/ https://www.ncbi.nlm.nih.gov/pubmed/38013674 http://dx.doi.org/10.1016/j.liver.2023.100146 |
work_keys_str_mv | AT kumaraman livertransplantationfromasarscov2positivedonoraroadaheadornot AT abbasdaniyal livertransplantationfromasarscov2positivedonoraroadaheadornot AT barrittasidney livertransplantationfromasarscov2positivedonoraroadaheadornot AT lachiewiczanne livertransplantationfromasarscov2positivedonoraroadaheadornot AT fixorenk livertransplantationfromasarscov2positivedonoraroadaheadornot AT desaichirags livertransplantationfromasarscov2positivedonoraroadaheadornot |