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Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not

The COVID-19 pandemic has had a remarkable impact on the field of liver transplantation. Increasing evidence demonstrates a minimal risk of transmission of SARS-CoV-2 from non-lung donors who test positive for SARS-CoV-2; however, the risks of donor-derived SARS-CoV-2 from liver donors are unknown....

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Autores principales: Kumar, Aman, Abbas, Daniyal, Barritt, A. Sidney, Lachiewicz, Anne, Fix, Oren K., Desai, Chirag S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Masson SAS. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951024/
https://www.ncbi.nlm.nih.gov/pubmed/38013674
http://dx.doi.org/10.1016/j.liver.2023.100146
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author Kumar, Aman
Abbas, Daniyal
Barritt, A. Sidney
Lachiewicz, Anne
Fix, Oren K.
Desai, Chirag S.
author_facet Kumar, Aman
Abbas, Daniyal
Barritt, A. Sidney
Lachiewicz, Anne
Fix, Oren K.
Desai, Chirag S.
author_sort Kumar, Aman
collection PubMed
description The COVID-19 pandemic has had a remarkable impact on the field of liver transplantation. Increasing evidence demonstrates a minimal risk of transmission of SARS-CoV-2 from non-lung donors who test positive for SARS-CoV-2; however, the risks of donor-derived SARS-CoV-2 from liver donors are unknown. We present our experience with two cases in which a liver was transplanted successfully from a brain-dead donor with incidental SARS-CoV-2 infection. Both donors were asymptomatic SARS-CoV-2-positive with negative bronchoalveolar lavage polymerase chain reaction (BAL PCR) and mechanism of death unrelated to COVID-19. Both the recipients did well after transplant and went home with a well-functioning liver. One patient did get readmitted and was found to be SARS-CoV-2-positive; however, it was probably related to hospital exposure rather than donor-derived. SARS-CoV-2-positive donors in select cases may be used for organ donation and liver transplant is safe for recipients.
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spelling pubmed-99510242023-02-24 Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not Kumar, Aman Abbas, Daniyal Barritt, A. Sidney Lachiewicz, Anne Fix, Oren K. Desai, Chirag S. Journal of Liver Transplantation Case Report The COVID-19 pandemic has had a remarkable impact on the field of liver transplantation. Increasing evidence demonstrates a minimal risk of transmission of SARS-CoV-2 from non-lung donors who test positive for SARS-CoV-2; however, the risks of donor-derived SARS-CoV-2 from liver donors are unknown. We present our experience with two cases in which a liver was transplanted successfully from a brain-dead donor with incidental SARS-CoV-2 infection. Both donors were asymptomatic SARS-CoV-2-positive with negative bronchoalveolar lavage polymerase chain reaction (BAL PCR) and mechanism of death unrelated to COVID-19. Both the recipients did well after transplant and went home with a well-functioning liver. One patient did get readmitted and was found to be SARS-CoV-2-positive; however, it was probably related to hospital exposure rather than donor-derived. SARS-CoV-2-positive donors in select cases may be used for organ donation and liver transplant is safe for recipients. The Author(s). Published by Elsevier Masson SAS. 2023-05 2023-02-24 /pmc/articles/PMC9951024/ /pubmed/38013674 http://dx.doi.org/10.1016/j.liver.2023.100146 Text en © 2023 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Kumar, Aman
Abbas, Daniyal
Barritt, A. Sidney
Lachiewicz, Anne
Fix, Oren K.
Desai, Chirag S.
Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not
title Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not
title_full Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not
title_fullStr Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not
title_full_unstemmed Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not
title_short Liver transplantation from a SARS-COV-2-positive donor: A road ahead or not
title_sort liver transplantation from a sars-cov-2-positive donor: a road ahead or not
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951024/
https://www.ncbi.nlm.nih.gov/pubmed/38013674
http://dx.doi.org/10.1016/j.liver.2023.100146
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