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Terminal hairpins improve protein expression in IRES-initiated mRNA in the absence of a cap and polyadenylated tail
Synthesizing mRNA in vitro is a standard and simple procedure. Adding the 5′ cap and 3′ polyadenylated (poly(A)) tail to make this mRNA functional for use as a vaccine or therapy increases the time and cost of production and usually decreases the yield, however. We designed mRNA that lacked a cap an...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951143/ https://www.ncbi.nlm.nih.gov/pubmed/36828937 http://dx.doi.org/10.1038/s41434-023-00391-4 |