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Detection of Streptococcus pyogenes M1(UK) in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA
A new variant of Streptococcus pyogenes serotype M1 (designated ‘M1(UK)’) has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen SpeA. The progenitor S. pyogenes ‘M1(global)’ a...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951164/ https://www.ncbi.nlm.nih.gov/pubmed/36828918 http://dx.doi.org/10.1038/s41467-023-36717-4 |
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| author | Davies, Mark R. Keller, Nadia Brouwer, Stephan Jespersen, Magnus G. Cork, Amanda J. Hayes, Andrew J. Pitt, Miranda E. De Oliveira, David M. P. Harbison-Price, Nichaela Bertolla, Olivia M. Mediati, Daniel G. Curren, Bodie F. Taiaroa, George Lacey, Jake A. Smith, Helen V. Fang, Ning-Xia Coin, Lachlan J. M. Stevens, Kerrie Tong, Steven Y. C. Sanderson-Smith, Martina Tree, Jai J. Irwin, Adam D. Grimwood, Keith Howden, Benjamin P. Jennison, Amy V. Walker, Mark J. |
| author_facet | Davies, Mark R. Keller, Nadia Brouwer, Stephan Jespersen, Magnus G. Cork, Amanda J. Hayes, Andrew J. Pitt, Miranda E. De Oliveira, David M. P. Harbison-Price, Nichaela Bertolla, Olivia M. Mediati, Daniel G. Curren, Bodie F. Taiaroa, George Lacey, Jake A. Smith, Helen V. Fang, Ning-Xia Coin, Lachlan J. M. Stevens, Kerrie Tong, Steven Y. C. Sanderson-Smith, Martina Tree, Jai J. Irwin, Adam D. Grimwood, Keith Howden, Benjamin P. Jennison, Amy V. Walker, Mark J. |
| author_sort | Davies, Mark R. |
| collection | PubMed |
| description | A new variant of Streptococcus pyogenes serotype M1 (designated ‘M1(UK)’) has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen SpeA. The progenitor S. pyogenes ‘M1(global)’ and M1(UK) clones can be differentiated by 27 SNPs and 4 indels, yet the mechanism for speA upregulation is unknown. Here we investigate the previously unappreciated expansion of M1(UK) in Australia, now isolated from the majority of serious infections caused by serotype M1 S. pyogenes. M1(UK) sub-lineages circulating in Australia also contain a novel toxin repertoire associated with epidemic scarlet fever causing S. pyogenes in Asia. A single SNP in the 5’ transcriptional leader sequence of the transfer-messenger RNA gene ssrA drives enhanced SpeA superantigen expression as a result of ssrA terminator read-through in the M1(UK) lineage. This represents a previously unappreciated mechanism of toxin expression and urges enhanced international surveillance. |
| format | Online Article Text |
| id | pubmed-9951164 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99511642023-02-24 Detection of Streptococcus pyogenes M1(UK) in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA Davies, Mark R. Keller, Nadia Brouwer, Stephan Jespersen, Magnus G. Cork, Amanda J. Hayes, Andrew J. Pitt, Miranda E. De Oliveira, David M. P. Harbison-Price, Nichaela Bertolla, Olivia M. Mediati, Daniel G. Curren, Bodie F. Taiaroa, George Lacey, Jake A. Smith, Helen V. Fang, Ning-Xia Coin, Lachlan J. M. Stevens, Kerrie Tong, Steven Y. C. Sanderson-Smith, Martina Tree, Jai J. Irwin, Adam D. Grimwood, Keith Howden, Benjamin P. Jennison, Amy V. Walker, Mark J. Nat Commun Article A new variant of Streptococcus pyogenes serotype M1 (designated ‘M1(UK)’) has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen SpeA. The progenitor S. pyogenes ‘M1(global)’ and M1(UK) clones can be differentiated by 27 SNPs and 4 indels, yet the mechanism for speA upregulation is unknown. Here we investigate the previously unappreciated expansion of M1(UK) in Australia, now isolated from the majority of serious infections caused by serotype M1 S. pyogenes. M1(UK) sub-lineages circulating in Australia also contain a novel toxin repertoire associated with epidemic scarlet fever causing S. pyogenes in Asia. A single SNP in the 5’ transcriptional leader sequence of the transfer-messenger RNA gene ssrA drives enhanced SpeA superantigen expression as a result of ssrA terminator read-through in the M1(UK) lineage. This represents a previously unappreciated mechanism of toxin expression and urges enhanced international surveillance. Nature Publishing Group UK 2023-02-24 /pmc/articles/PMC9951164/ /pubmed/36828918 http://dx.doi.org/10.1038/s41467-023-36717-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Davies, Mark R. Keller, Nadia Brouwer, Stephan Jespersen, Magnus G. Cork, Amanda J. Hayes, Andrew J. Pitt, Miranda E. De Oliveira, David M. P. Harbison-Price, Nichaela Bertolla, Olivia M. Mediati, Daniel G. Curren, Bodie F. Taiaroa, George Lacey, Jake A. Smith, Helen V. Fang, Ning-Xia Coin, Lachlan J. M. Stevens, Kerrie Tong, Steven Y. C. Sanderson-Smith, Martina Tree, Jai J. Irwin, Adam D. Grimwood, Keith Howden, Benjamin P. Jennison, Amy V. Walker, Mark J. Detection of Streptococcus pyogenes M1(UK) in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA |
| title | Detection of Streptococcus pyogenes M1(UK) in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA |
| title_full | Detection of Streptococcus pyogenes M1(UK) in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA |
| title_fullStr | Detection of Streptococcus pyogenes M1(UK) in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA |
| title_full_unstemmed | Detection of Streptococcus pyogenes M1(UK) in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA |
| title_short | Detection of Streptococcus pyogenes M1(UK) in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA |
| title_sort | detection of streptococcus pyogenes m1(uk) in australia and characterization of the mutation driving enhanced expression of superantigen spea |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951164/ https://www.ncbi.nlm.nih.gov/pubmed/36828918 http://dx.doi.org/10.1038/s41467-023-36717-4 |
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