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Mesoporous Silica Particles Retain Their Structure and Function while Passing through the Gastrointestinal Tracts of Mice and Humans
[Image: see text] Mesoporous silica particles (MSPs) can be used as food additives, clinically for therapeutic applications, or as oral delivery vehicles. It has also been discussed to be used for a number of novel applications including treatment for diabetes and obesity. However, a major question...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951217/ https://www.ncbi.nlm.nih.gov/pubmed/36731867 http://dx.doi.org/10.1021/acsami.2c16710 |
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author | Iqbal, Muhammad Naeem Robert-Nicoud, Ghislaine Ciurans-Oset, Marina Akhtar, Farid Hedin, Niklas Bengtsson, Tore |
author_facet | Iqbal, Muhammad Naeem Robert-Nicoud, Ghislaine Ciurans-Oset, Marina Akhtar, Farid Hedin, Niklas Bengtsson, Tore |
author_sort | Iqbal, Muhammad Naeem |
collection | PubMed |
description | [Image: see text] Mesoporous silica particles (MSPs) can be used as food additives, clinically for therapeutic applications, or as oral delivery vehicles. It has also been discussed to be used for a number of novel applications including treatment for diabetes and obesity. However, a major question for their possible usage has been if these particles persist structurally and retain their effect when passing through the gastrointestinal tract (GIT). A substantial breaking down of the particles could reduce function and be clinically problematic for safety issues. Hence, we investigated the biostability of MSPs of the SBA-15 kind prepared at large scales (100 and 1000 L). The MSPs were orally administered in a murine model and clinically in humans. A joint extraction and calcination method was developed to recover the MSPs from fecal mass, and the MSPs were characterized physically, structurally, morphologically, and functionally before and after GIT passage. Analyses with N(2) adsorption, X-ray diffraction, electron microscopy, and as a proxy for general function, adsorption of the enzyme α-amylase, were conducted. The adsorption capacity of α-amylase on extracted MSPs was not reduced as compared to the pristine and control MSPs, and adsorption of up to 17% (w/w) was measured. It was demonstrated that the particles did not break down to any substantial degree and retained their function after passing through the GITs of the murine model and in humans. The fact the particles were not absorbed into the body was ascribed to that they were micron-sized and ingested as agglomerates and too big to pass the intestinal barrier. The results strongly suggest that orally ingested MSPs can be used for a number of clinical applications. |
format | Online Article Text |
id | pubmed-9951217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-99512172023-02-25 Mesoporous Silica Particles Retain Their Structure and Function while Passing through the Gastrointestinal Tracts of Mice and Humans Iqbal, Muhammad Naeem Robert-Nicoud, Ghislaine Ciurans-Oset, Marina Akhtar, Farid Hedin, Niklas Bengtsson, Tore ACS Appl Mater Interfaces [Image: see text] Mesoporous silica particles (MSPs) can be used as food additives, clinically for therapeutic applications, or as oral delivery vehicles. It has also been discussed to be used for a number of novel applications including treatment for diabetes and obesity. However, a major question for their possible usage has been if these particles persist structurally and retain their effect when passing through the gastrointestinal tract (GIT). A substantial breaking down of the particles could reduce function and be clinically problematic for safety issues. Hence, we investigated the biostability of MSPs of the SBA-15 kind prepared at large scales (100 and 1000 L). The MSPs were orally administered in a murine model and clinically in humans. A joint extraction and calcination method was developed to recover the MSPs from fecal mass, and the MSPs were characterized physically, structurally, morphologically, and functionally before and after GIT passage. Analyses with N(2) adsorption, X-ray diffraction, electron microscopy, and as a proxy for general function, adsorption of the enzyme α-amylase, were conducted. The adsorption capacity of α-amylase on extracted MSPs was not reduced as compared to the pristine and control MSPs, and adsorption of up to 17% (w/w) was measured. It was demonstrated that the particles did not break down to any substantial degree and retained their function after passing through the GITs of the murine model and in humans. The fact the particles were not absorbed into the body was ascribed to that they were micron-sized and ingested as agglomerates and too big to pass the intestinal barrier. The results strongly suggest that orally ingested MSPs can be used for a number of clinical applications. American Chemical Society 2023-02-02 /pmc/articles/PMC9951217/ /pubmed/36731867 http://dx.doi.org/10.1021/acsami.2c16710 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Iqbal, Muhammad Naeem Robert-Nicoud, Ghislaine Ciurans-Oset, Marina Akhtar, Farid Hedin, Niklas Bengtsson, Tore Mesoporous Silica Particles Retain Their Structure and Function while Passing through the Gastrointestinal Tracts of Mice and Humans |
title | Mesoporous
Silica
Particles Retain Their Structure
and Function while Passing through the Gastrointestinal Tracts of
Mice and Humans |
title_full | Mesoporous
Silica
Particles Retain Their Structure
and Function while Passing through the Gastrointestinal Tracts of
Mice and Humans |
title_fullStr | Mesoporous
Silica
Particles Retain Their Structure
and Function while Passing through the Gastrointestinal Tracts of
Mice and Humans |
title_full_unstemmed | Mesoporous
Silica
Particles Retain Their Structure
and Function while Passing through the Gastrointestinal Tracts of
Mice and Humans |
title_short | Mesoporous
Silica
Particles Retain Their Structure
and Function while Passing through the Gastrointestinal Tracts of
Mice and Humans |
title_sort | mesoporous
silica
particles retain their structure
and function while passing through the gastrointestinal tracts of
mice and humans |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951217/ https://www.ncbi.nlm.nih.gov/pubmed/36731867 http://dx.doi.org/10.1021/acsami.2c16710 |
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