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Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis
[Image: see text] As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C–O bond form...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951252/ https://www.ncbi.nlm.nih.gov/pubmed/36763788 http://dx.doi.org/10.1021/jacs.2c12779 |
| Sumario: | [Image: see text] As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C–O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis. |
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