Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis

[Image: see text] As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C–O bond form...

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Autores principales: Li, Qi, Wang, Zhen, Dong, Vy M., Yang, Xiao-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951252/
https://www.ncbi.nlm.nih.gov/pubmed/36763788
http://dx.doi.org/10.1021/jacs.2c12779
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author Li, Qi
Wang, Zhen
Dong, Vy M.
Yang, Xiao-Hui
author_facet Li, Qi
Wang, Zhen
Dong, Vy M.
Yang, Xiao-Hui
author_sort Li, Qi
collection PubMed
description [Image: see text] As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C–O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.
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spelling pubmed-99512522023-02-25 Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis Li, Qi Wang, Zhen Dong, Vy M. Yang, Xiao-Hui J Am Chem Soc [Image: see text] As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C–O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis. American Chemical Society 2023-02-10 /pmc/articles/PMC9951252/ /pubmed/36763788 http://dx.doi.org/10.1021/jacs.2c12779 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Li, Qi
Wang, Zhen
Dong, Vy M.
Yang, Xiao-Hui
Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis
title Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis
title_full Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis
title_fullStr Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis
title_full_unstemmed Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis
title_short Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis
title_sort enantioselective hydroalkoxylation of 1,3-dienes via ni-catalysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951252/
https://www.ncbi.nlm.nih.gov/pubmed/36763788
http://dx.doi.org/10.1021/jacs.2c12779
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