The role of O-GlcNAcylation in innate immunity and inflammation

O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a highly dynamic and widespread post-translational modification (PTM) that regulates the activity, subcellular localization, and stability of target proteins. O-GlcNAcylation is a reversible PTM controlled by two cycling enzymes: O-linked N-a...

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Autores principales: Wang, Yongqiang, Fang, Xiuwu, Wang, Shuai, Wang, Bin, Chu, Feng, Tian, Zhixin, Zhang, Long, Zhou, Fangfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951266/
https://www.ncbi.nlm.nih.gov/pubmed/36473120
http://dx.doi.org/10.1093/jmcb/mjac065
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author Wang, Yongqiang
Fang, Xiuwu
Wang, Shuai
Wang, Bin
Chu, Feng
Tian, Zhixin
Zhang, Long
Zhou, Fangfang
author_facet Wang, Yongqiang
Fang, Xiuwu
Wang, Shuai
Wang, Bin
Chu, Feng
Tian, Zhixin
Zhang, Long
Zhou, Fangfang
author_sort Wang, Yongqiang
collection PubMed
description O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a highly dynamic and widespread post-translational modification (PTM) that regulates the activity, subcellular localization, and stability of target proteins. O-GlcNAcylation is a reversible PTM controlled by two cycling enzymes: O-linked N-acetylglucosamine transferase and O-GlcNAcase. Emerging evidence indicates that O-GlcNAcylation plays critical roles in innate immunity, inflammatory signaling, and cancer development. O-GlcNAcylation usually occurs on serine/threonine residues, where it interacts with other PTMs, such as phosphorylation. Thus, it likely has a broad regulatory scope. This review discusses the recent research advances regarding the regulatory roles of O-GlcNAcylation in innate immunity and inflammation. A more comprehensive understanding of O-GlcNAcylation could help to optimize therapeutic strategies regarding inflammatory diseases and cancer.
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spelling pubmed-99512662023-02-25 The role of O-GlcNAcylation in innate immunity and inflammation Wang, Yongqiang Fang, Xiuwu Wang, Shuai Wang, Bin Chu, Feng Tian, Zhixin Zhang, Long Zhou, Fangfang J Mol Cell Biol Review O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a highly dynamic and widespread post-translational modification (PTM) that regulates the activity, subcellular localization, and stability of target proteins. O-GlcNAcylation is a reversible PTM controlled by two cycling enzymes: O-linked N-acetylglucosamine transferase and O-GlcNAcase. Emerging evidence indicates that O-GlcNAcylation plays critical roles in innate immunity, inflammatory signaling, and cancer development. O-GlcNAcylation usually occurs on serine/threonine residues, where it interacts with other PTMs, such as phosphorylation. Thus, it likely has a broad regulatory scope. This review discusses the recent research advances regarding the regulatory roles of O-GlcNAcylation in innate immunity and inflammation. A more comprehensive understanding of O-GlcNAcylation could help to optimize therapeutic strategies regarding inflammatory diseases and cancer. Oxford University Press 2022-12-06 /pmc/articles/PMC9951266/ /pubmed/36473120 http://dx.doi.org/10.1093/jmcb/mjac065 Text en © The Author(s) (2022). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, CEMCS, CAS. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Wang, Yongqiang
Fang, Xiuwu
Wang, Shuai
Wang, Bin
Chu, Feng
Tian, Zhixin
Zhang, Long
Zhou, Fangfang
The role of O-GlcNAcylation in innate immunity and inflammation
title The role of O-GlcNAcylation in innate immunity and inflammation
title_full The role of O-GlcNAcylation in innate immunity and inflammation
title_fullStr The role of O-GlcNAcylation in innate immunity and inflammation
title_full_unstemmed The role of O-GlcNAcylation in innate immunity and inflammation
title_short The role of O-GlcNAcylation in innate immunity and inflammation
title_sort role of o-glcnacylation in innate immunity and inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951266/
https://www.ncbi.nlm.nih.gov/pubmed/36473120
http://dx.doi.org/10.1093/jmcb/mjac065
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