Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis (Adv. Sci. 6/2023)

Whole‐Cell Biocatalysts In the article 2205580, Xinrui Zhao and co‐workers report an engineered Escherichia coli strain capable of improved heme supply suitable for whole‐cell P450 biocatalysis. The intracellular heme level is fine‐tuned by the combined use of mutated heme‐sensitive biosensor and sm...

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Detalles Bibliográficos
Autores principales: Hu, Baodong, Yu, Haibo, Zhou, Jingwen, Li, Jianghua, Chen, Jian, Du, Guocheng, Lee, Sang Yup, Zhao, Xinrui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Inside Front Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951303/
http://dx.doi.org/10.1002/advs.202370031
Descripción
Sumario:Whole‐Cell Biocatalysts In the article 2205580, Xinrui Zhao and co‐workers report an engineered Escherichia coli strain capable of improved heme supply suitable for whole‐cell P450 biocatalysis. The intracellular heme level is fine‐tuned by the combined use of mutated heme‐sensitive biosensor and small regulatory RNA systems. [Image: see text]

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