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Role of precision medicine in obstructive sleep apnoea

Obstructive sleep apnoea is a substantial clinical and public health problem because it contributes to harmful effects on quality of life, daytime symptoms, road traffic incidents, and cardiometabolic disease. Increasingly, obstructive sleep apnoea is recognised as a heterogeneous disease, and patie...

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Autores principales: Liu, Yu, Abdul Ghafoor, Ali, Hajipour, Mohammadreza, Ayas, Najib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951383/
https://www.ncbi.nlm.nih.gov/pubmed/36936264
http://dx.doi.org/10.1136/bmjmed-2022-000218
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author Liu, Yu
Abdul Ghafoor, Ali
Hajipour, Mohammadreza
Ayas, Najib
author_facet Liu, Yu
Abdul Ghafoor, Ali
Hajipour, Mohammadreza
Ayas, Najib
author_sort Liu, Yu
collection PubMed
description Obstructive sleep apnoea is a substantial clinical and public health problem because it contributes to harmful effects on quality of life, daytime symptoms, road traffic incidents, and cardiometabolic disease. Increasingly, obstructive sleep apnoea is recognised as a heterogeneous disease, and patients have varied susceptibility to long term complications and different responses to treatment. This narrative review summarises the current knowledge of precision medicine in obstructive sleep apnoea, particularly the role of symptom clusters, polysomnogram phenotypes, physiological endotypes, and circulating biomarkers in defining subtypes. In the near future, the prognostic accuracy of these measures in predicting long term complications in obstructive sleep apnoea will likely be improved, together with better matching of treatments to disease subtypes.
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spelling pubmed-99513832023-03-16 Role of precision medicine in obstructive sleep apnoea Liu, Yu Abdul Ghafoor, Ali Hajipour, Mohammadreza Ayas, Najib BMJ Med Review Obstructive sleep apnoea is a substantial clinical and public health problem because it contributes to harmful effects on quality of life, daytime symptoms, road traffic incidents, and cardiometabolic disease. Increasingly, obstructive sleep apnoea is recognised as a heterogeneous disease, and patients have varied susceptibility to long term complications and different responses to treatment. This narrative review summarises the current knowledge of precision medicine in obstructive sleep apnoea, particularly the role of symptom clusters, polysomnogram phenotypes, physiological endotypes, and circulating biomarkers in defining subtypes. In the near future, the prognostic accuracy of these measures in predicting long term complications in obstructive sleep apnoea will likely be improved, together with better matching of treatments to disease subtypes. BMJ Publishing Group 2023-01-05 /pmc/articles/PMC9951383/ /pubmed/36936264 http://dx.doi.org/10.1136/bmjmed-2022-000218 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Liu, Yu
Abdul Ghafoor, Ali
Hajipour, Mohammadreza
Ayas, Najib
Role of precision medicine in obstructive sleep apnoea
title Role of precision medicine in obstructive sleep apnoea
title_full Role of precision medicine in obstructive sleep apnoea
title_fullStr Role of precision medicine in obstructive sleep apnoea
title_full_unstemmed Role of precision medicine in obstructive sleep apnoea
title_short Role of precision medicine in obstructive sleep apnoea
title_sort role of precision medicine in obstructive sleep apnoea
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951383/
https://www.ncbi.nlm.nih.gov/pubmed/36936264
http://dx.doi.org/10.1136/bmjmed-2022-000218
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