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Allosteric Activation of 15‐Lipoxygenase‐1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation

Specialized pro‐resolving mediators (SPM), primarily produced in innate immune cells, exert crucial bioactions for resolving inflammation. Among various lipoxygenases (LOX), 15‐LOX‐1 is key for SPM biosynthesis, but cellular activation principles of 15‐LOX‐1 are unexplored. It was shown that 3‐O‐ace...

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Detalles Bibliográficos
Autores principales:	Börner, Friedemann, Pace, Simona, Jordan, Paul M., Gerstmeier, Jana, Gomez, Mario, Rossi, Antonietta, Gilbert, Nathaniel C., Newcomer, Marcia E., Werz, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951388/ https://www.ncbi.nlm.nih.gov/pubmed/36567268 http://dx.doi.org/10.1002/advs.202205604

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