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Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities

Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle is not beneficial to health. Exercise can promote many enabling pathways, particularly through circulating exerkines, to optimize individual health and quality of life. Such benefits might explain the protect...

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Autores principales: Trettel, Caio dos Santos, Pelozin, Bruno Rocha de Avila, Barros, Marcelo Paes, Bachi, André Luis Lacerda, Braga, Pedro Gabriel Senger, Momesso, César Miguel, Furtado, Guilherme Eustáquio, Valente, Pedro Afonso, Oliveira, Edilamar Menezes, Hogervorst, Eef, Fernandes, Tiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951776/
https://www.ncbi.nlm.nih.gov/pubmed/36843614
http://dx.doi.org/10.3389/fendo.2023.1106529
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author Trettel, Caio dos Santos
Pelozin, Bruno Rocha de Avila
Barros, Marcelo Paes
Bachi, André Luis Lacerda
Braga, Pedro Gabriel Senger
Momesso, César Miguel
Furtado, Guilherme Eustáquio
Valente, Pedro Afonso
Oliveira, Edilamar Menezes
Hogervorst, Eef
Fernandes, Tiago
author_facet Trettel, Caio dos Santos
Pelozin, Bruno Rocha de Avila
Barros, Marcelo Paes
Bachi, André Luis Lacerda
Braga, Pedro Gabriel Senger
Momesso, César Miguel
Furtado, Guilherme Eustáquio
Valente, Pedro Afonso
Oliveira, Edilamar Menezes
Hogervorst, Eef
Fernandes, Tiago
author_sort Trettel, Caio dos Santos
collection PubMed
description Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle is not beneficial to health. Exercise can promote many enabling pathways, particularly through circulating exerkines, to optimize individual health and quality of life. Such benefits might explain the protective effects of exercise against aging and noncommunicable diseases. Nevertheless, the miRNA-mediated molecular mechanisms and exerkine interorgan crosstalk that underlie the beneficial effects of exercise remain poorly understood. In this mini review, we focused on the exerkine, irisin, mainly produced by muscle contraction during adaptation to exercise and its beneficial effects on body homeostasis. Herein, the complex role of irisin in metabolism and inflammation is described, including its subsequent effects on thermogenesis through browning to control obesity and improve glycemic regulation for diabetes mellitus control, its potential to improve cognitive function (via brain derived neurotrophic factor), and its pathways of action and role in aging.
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spelling pubmed-99517762023-02-25 Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities Trettel, Caio dos Santos Pelozin, Bruno Rocha de Avila Barros, Marcelo Paes Bachi, André Luis Lacerda Braga, Pedro Gabriel Senger Momesso, César Miguel Furtado, Guilherme Eustáquio Valente, Pedro Afonso Oliveira, Edilamar Menezes Hogervorst, Eef Fernandes, Tiago Front Endocrinol (Lausanne) Endocrinology Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle is not beneficial to health. Exercise can promote many enabling pathways, particularly through circulating exerkines, to optimize individual health and quality of life. Such benefits might explain the protective effects of exercise against aging and noncommunicable diseases. Nevertheless, the miRNA-mediated molecular mechanisms and exerkine interorgan crosstalk that underlie the beneficial effects of exercise remain poorly understood. In this mini review, we focused on the exerkine, irisin, mainly produced by muscle contraction during adaptation to exercise and its beneficial effects on body homeostasis. Herein, the complex role of irisin in metabolism and inflammation is described, including its subsequent effects on thermogenesis through browning to control obesity and improve glycemic regulation for diabetes mellitus control, its potential to improve cognitive function (via brain derived neurotrophic factor), and its pathways of action and role in aging. Frontiers Media S.A. 2023-02-10 /pmc/articles/PMC9951776/ /pubmed/36843614 http://dx.doi.org/10.3389/fendo.2023.1106529 Text en Copyright © 2023 Trettel, Pelozin, Barros, Bachi, Braga, Momesso, Furtado, Valente, Oliveira, Hogervorst and Fernandes https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Trettel, Caio dos Santos
Pelozin, Bruno Rocha de Avila
Barros, Marcelo Paes
Bachi, André Luis Lacerda
Braga, Pedro Gabriel Senger
Momesso, César Miguel
Furtado, Guilherme Eustáquio
Valente, Pedro Afonso
Oliveira, Edilamar Menezes
Hogervorst, Eef
Fernandes, Tiago
Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities
title Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities
title_full Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities
title_fullStr Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities
title_full_unstemmed Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities
title_short Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities
title_sort irisin: an anti-inflammatory exerkine in aging and redox-mediated comorbidities
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951776/
https://www.ncbi.nlm.nih.gov/pubmed/36843614
http://dx.doi.org/10.3389/fendo.2023.1106529
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