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Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities
Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle is not beneficial to health. Exercise can promote many enabling pathways, particularly through circulating exerkines, to optimize individual health and quality of life. Such benefits might explain the protect...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951776/ https://www.ncbi.nlm.nih.gov/pubmed/36843614 http://dx.doi.org/10.3389/fendo.2023.1106529 |
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author | Trettel, Caio dos Santos Pelozin, Bruno Rocha de Avila Barros, Marcelo Paes Bachi, André Luis Lacerda Braga, Pedro Gabriel Senger Momesso, César Miguel Furtado, Guilherme Eustáquio Valente, Pedro Afonso Oliveira, Edilamar Menezes Hogervorst, Eef Fernandes, Tiago |
author_facet | Trettel, Caio dos Santos Pelozin, Bruno Rocha de Avila Barros, Marcelo Paes Bachi, André Luis Lacerda Braga, Pedro Gabriel Senger Momesso, César Miguel Furtado, Guilherme Eustáquio Valente, Pedro Afonso Oliveira, Edilamar Menezes Hogervorst, Eef Fernandes, Tiago |
author_sort | Trettel, Caio dos Santos |
collection | PubMed |
description | Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle is not beneficial to health. Exercise can promote many enabling pathways, particularly through circulating exerkines, to optimize individual health and quality of life. Such benefits might explain the protective effects of exercise against aging and noncommunicable diseases. Nevertheless, the miRNA-mediated molecular mechanisms and exerkine interorgan crosstalk that underlie the beneficial effects of exercise remain poorly understood. In this mini review, we focused on the exerkine, irisin, mainly produced by muscle contraction during adaptation to exercise and its beneficial effects on body homeostasis. Herein, the complex role of irisin in metabolism and inflammation is described, including its subsequent effects on thermogenesis through browning to control obesity and improve glycemic regulation for diabetes mellitus control, its potential to improve cognitive function (via brain derived neurotrophic factor), and its pathways of action and role in aging. |
format | Online Article Text |
id | pubmed-9951776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99517762023-02-25 Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities Trettel, Caio dos Santos Pelozin, Bruno Rocha de Avila Barros, Marcelo Paes Bachi, André Luis Lacerda Braga, Pedro Gabriel Senger Momesso, César Miguel Furtado, Guilherme Eustáquio Valente, Pedro Afonso Oliveira, Edilamar Menezes Hogervorst, Eef Fernandes, Tiago Front Endocrinol (Lausanne) Endocrinology Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle is not beneficial to health. Exercise can promote many enabling pathways, particularly through circulating exerkines, to optimize individual health and quality of life. Such benefits might explain the protective effects of exercise against aging and noncommunicable diseases. Nevertheless, the miRNA-mediated molecular mechanisms and exerkine interorgan crosstalk that underlie the beneficial effects of exercise remain poorly understood. In this mini review, we focused on the exerkine, irisin, mainly produced by muscle contraction during adaptation to exercise and its beneficial effects on body homeostasis. Herein, the complex role of irisin in metabolism and inflammation is described, including its subsequent effects on thermogenesis through browning to control obesity and improve glycemic regulation for diabetes mellitus control, its potential to improve cognitive function (via brain derived neurotrophic factor), and its pathways of action and role in aging. Frontiers Media S.A. 2023-02-10 /pmc/articles/PMC9951776/ /pubmed/36843614 http://dx.doi.org/10.3389/fendo.2023.1106529 Text en Copyright © 2023 Trettel, Pelozin, Barros, Bachi, Braga, Momesso, Furtado, Valente, Oliveira, Hogervorst and Fernandes https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Trettel, Caio dos Santos Pelozin, Bruno Rocha de Avila Barros, Marcelo Paes Bachi, André Luis Lacerda Braga, Pedro Gabriel Senger Momesso, César Miguel Furtado, Guilherme Eustáquio Valente, Pedro Afonso Oliveira, Edilamar Menezes Hogervorst, Eef Fernandes, Tiago Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities |
title | Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities |
title_full | Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities |
title_fullStr | Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities |
title_full_unstemmed | Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities |
title_short | Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities |
title_sort | irisin: an anti-inflammatory exerkine in aging and redox-mediated comorbidities |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951776/ https://www.ncbi.nlm.nih.gov/pubmed/36843614 http://dx.doi.org/10.3389/fendo.2023.1106529 |
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