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Hepatitis C Virus Dynamic Transmission Models Among People Who Inject Drugs

BACKGROUND: Transmission dynamic model is a concrete structure to describe and investigate the complex system of host–pathogen interactions. Hepatitis C virus (HCV) is a blood-borne virus that is transmitted from infectious to susceptible individuals when they come into contact with HCV-contaminated...

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Autores principales: Woyesa, Shiferaw Bekele, Amente, Kellemuwa Desalegn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951810/
https://www.ncbi.nlm.nih.gov/pubmed/36845020
http://dx.doi.org/10.2147/IDR.S403133
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author Woyesa, Shiferaw Bekele
Amente, Kellemuwa Desalegn
author_facet Woyesa, Shiferaw Bekele
Amente, Kellemuwa Desalegn
author_sort Woyesa, Shiferaw Bekele
collection PubMed
description BACKGROUND: Transmission dynamic model is a concrete structure to describe and investigate the complex system of host–pathogen interactions. Hepatitis C virus (HCV) is a blood-borne virus that is transmitted from infectious to susceptible individuals when they come into contact with HCV-contaminated equipment. Injecting drug use is the most known transmission route, and about 80% of new HCV cases have been confirmed as having acquired HCV infection via drug injection. OBJECTIVE: The main objective of this review paper was to review the importance of HCV dynamic transmission model, that enables the readers to understand the mechanism how HCV is transmissible from infectious to susceptible hosts and the effective controlling strategies. METHODS: PubMed Central, Google Scholar, and Web of Science electronic databases have been used to search data by using key terms like “HCV transmission model among people who inject drug (PWID)”, HCV potential herd immunity”, and “basic reproductive number for HCV transmission in PWID.” Data from research findings other than English version have been excluded from being used, and the most recently published data have been considered to be included. CONCLUSION: HCV belongs to the Hepacivirus genus within the Flaviviridae family. HCV infection is acquired when the susceptible individuals in populations come into contact with medical equipment such as shared syringes and needles, or swabs contaminated with infected blood. Construction of HCV transmission dynamic model is very significant in order to predict the duration and magnitude of its epidemic and to evaluate the potential impact of intervention. Comprehensive harm reduction and care/support service strategies are the best approach for intervention regarding HCV infection transmission among PWID.
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spelling pubmed-99518102023-02-25 Hepatitis C Virus Dynamic Transmission Models Among People Who Inject Drugs Woyesa, Shiferaw Bekele Amente, Kellemuwa Desalegn Infect Drug Resist Review BACKGROUND: Transmission dynamic model is a concrete structure to describe and investigate the complex system of host–pathogen interactions. Hepatitis C virus (HCV) is a blood-borne virus that is transmitted from infectious to susceptible individuals when they come into contact with HCV-contaminated equipment. Injecting drug use is the most known transmission route, and about 80% of new HCV cases have been confirmed as having acquired HCV infection via drug injection. OBJECTIVE: The main objective of this review paper was to review the importance of HCV dynamic transmission model, that enables the readers to understand the mechanism how HCV is transmissible from infectious to susceptible hosts and the effective controlling strategies. METHODS: PubMed Central, Google Scholar, and Web of Science electronic databases have been used to search data by using key terms like “HCV transmission model among people who inject drug (PWID)”, HCV potential herd immunity”, and “basic reproductive number for HCV transmission in PWID.” Data from research findings other than English version have been excluded from being used, and the most recently published data have been considered to be included. CONCLUSION: HCV belongs to the Hepacivirus genus within the Flaviviridae family. HCV infection is acquired when the susceptible individuals in populations come into contact with medical equipment such as shared syringes and needles, or swabs contaminated with infected blood. Construction of HCV transmission dynamic model is very significant in order to predict the duration and magnitude of its epidemic and to evaluate the potential impact of intervention. Comprehensive harm reduction and care/support service strategies are the best approach for intervention regarding HCV infection transmission among PWID. Dove 2023-02-20 /pmc/articles/PMC9951810/ /pubmed/36845020 http://dx.doi.org/10.2147/IDR.S403133 Text en © 2023 Woyesa and Amente. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Woyesa, Shiferaw Bekele
Amente, Kellemuwa Desalegn
Hepatitis C Virus Dynamic Transmission Models Among People Who Inject Drugs
title Hepatitis C Virus Dynamic Transmission Models Among People Who Inject Drugs
title_full Hepatitis C Virus Dynamic Transmission Models Among People Who Inject Drugs
title_fullStr Hepatitis C Virus Dynamic Transmission Models Among People Who Inject Drugs
title_full_unstemmed Hepatitis C Virus Dynamic Transmission Models Among People Who Inject Drugs
title_short Hepatitis C Virus Dynamic Transmission Models Among People Who Inject Drugs
title_sort hepatitis c virus dynamic transmission models among people who inject drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951810/
https://www.ncbi.nlm.nih.gov/pubmed/36845020
http://dx.doi.org/10.2147/IDR.S403133
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