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Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease
Curcumin, a bioactive phenol derived from turmeric, is an antioxidant, anti-inflammatory, and antibacterial molecule. Although curcumin exhibits beneficial effects in its innate form, it is highly hydrophobic, which leads to poor water solubility and, consequently, low bioavailability. The lack of b...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951943/ https://www.ncbi.nlm.nih.gov/pubmed/36829756 http://dx.doi.org/10.3390/bioengineering10020262 |
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author | Hamilton, Adelle E. Gilbert, Ryan J. |
author_facet | Hamilton, Adelle E. Gilbert, Ryan J. |
author_sort | Hamilton, Adelle E. |
collection | PubMed |
description | Curcumin, a bioactive phenol derived from turmeric, is an antioxidant, anti-inflammatory, and antibacterial molecule. Although curcumin exhibits beneficial effects in its innate form, it is highly hydrophobic, which leads to poor water solubility and, consequently, low bioavailability. The lack of bioavailability limits curcumin’s effectiveness as a treatment and restricts its use in clinical applications. Furthermore, to achieve beneficial, clinically relevant results, high doses of curcumin are required for systemic administration. Many researchers have utilized biomaterial carriers, including electrospun fibers, nanoparticles, hydrogels, and composite scaffolds, to overcome curcumin’s principle therapeutic limitation of low bioavailability. By using biomaterials to deliver curcumin directly to injury sites, researchers have harnessed the beneficial natural properties of curcumin while providing scaffolding to support tissue regeneration. This review will provide an in-depth overview of the literature that utilizes biomaterial delivery of curcumin for tissue regeneration in injury and disease models. |
format | Online Article Text |
id | pubmed-9951943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99519432023-02-25 Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease Hamilton, Adelle E. Gilbert, Ryan J. Bioengineering (Basel) Review Curcumin, a bioactive phenol derived from turmeric, is an antioxidant, anti-inflammatory, and antibacterial molecule. Although curcumin exhibits beneficial effects in its innate form, it is highly hydrophobic, which leads to poor water solubility and, consequently, low bioavailability. The lack of bioavailability limits curcumin’s effectiveness as a treatment and restricts its use in clinical applications. Furthermore, to achieve beneficial, clinically relevant results, high doses of curcumin are required for systemic administration. Many researchers have utilized biomaterial carriers, including electrospun fibers, nanoparticles, hydrogels, and composite scaffolds, to overcome curcumin’s principle therapeutic limitation of low bioavailability. By using biomaterials to deliver curcumin directly to injury sites, researchers have harnessed the beneficial natural properties of curcumin while providing scaffolding to support tissue regeneration. This review will provide an in-depth overview of the literature that utilizes biomaterial delivery of curcumin for tissue regeneration in injury and disease models. MDPI 2023-02-16 /pmc/articles/PMC9951943/ /pubmed/36829756 http://dx.doi.org/10.3390/bioengineering10020262 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hamilton, Adelle E. Gilbert, Ryan J. Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease |
title | Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease |
title_full | Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease |
title_fullStr | Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease |
title_full_unstemmed | Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease |
title_short | Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease |
title_sort | curcumin release from biomaterials for enhanced tissue regeneration following injury or disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951943/ https://www.ncbi.nlm.nih.gov/pubmed/36829756 http://dx.doi.org/10.3390/bioengineering10020262 |
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