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Generation of Highly Antioxidant Submicron Particles from Myrtus communis Leaf Extract by Supercritical Antisolvent Extraction Process
Submicron particles have been produced from an ethanolic extract of Myrtus communnis leaves using supercritical carbon dioxide technology, hereinafter referred to as Supercritical Antisolvent Extraction (SAE). The influence of pressure (9–20 MPa), temperature (308 and 328 K) and injection rate (3 an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951993/ https://www.ncbi.nlm.nih.gov/pubmed/36830088 http://dx.doi.org/10.3390/antiox12020530 |
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author | Valor, Diego Montes, Antonio Calderón-Domínguez, María Aghziel, Inass Sánchez-Gomar, Ismael Alcalá, Martín Durán-Ruiz, Ma Carmen Pereyra, Clara |
author_facet | Valor, Diego Montes, Antonio Calderón-Domínguez, María Aghziel, Inass Sánchez-Gomar, Ismael Alcalá, Martín Durán-Ruiz, Ma Carmen Pereyra, Clara |
author_sort | Valor, Diego |
collection | PubMed |
description | Submicron particles have been produced from an ethanolic extract of Myrtus communnis leaves using supercritical carbon dioxide technology, hereinafter referred to as Supercritical Antisolvent Extraction (SAE). The influence of pressure (9–20 MPa), temperature (308 and 328 K) and injection rate (3 and 8 mL/min) on the particles’ precipitation has been investigated, and it has been confirmed that increases in pressure and temperature led to smaller particle sizes. The obtained particles had a quasi-spherical shape with sizes ranging from 0.42 to 1.32 μm. Moreover, the bioactivity of the generated particles was assessed and large contents of phenolic compounds with a high antioxidant activity were measured. The particles were also subjected to in vitro studies against oxidative stress. The myrtle particles demonstrated cytoprotective properties when applied at low concentrations (1 μM) to macrophage cell lines. |
format | Online Article Text |
id | pubmed-9951993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99519932023-02-25 Generation of Highly Antioxidant Submicron Particles from Myrtus communis Leaf Extract by Supercritical Antisolvent Extraction Process Valor, Diego Montes, Antonio Calderón-Domínguez, María Aghziel, Inass Sánchez-Gomar, Ismael Alcalá, Martín Durán-Ruiz, Ma Carmen Pereyra, Clara Antioxidants (Basel) Article Submicron particles have been produced from an ethanolic extract of Myrtus communnis leaves using supercritical carbon dioxide technology, hereinafter referred to as Supercritical Antisolvent Extraction (SAE). The influence of pressure (9–20 MPa), temperature (308 and 328 K) and injection rate (3 and 8 mL/min) on the particles’ precipitation has been investigated, and it has been confirmed that increases in pressure and temperature led to smaller particle sizes. The obtained particles had a quasi-spherical shape with sizes ranging from 0.42 to 1.32 μm. Moreover, the bioactivity of the generated particles was assessed and large contents of phenolic compounds with a high antioxidant activity were measured. The particles were also subjected to in vitro studies against oxidative stress. The myrtle particles demonstrated cytoprotective properties when applied at low concentrations (1 μM) to macrophage cell lines. MDPI 2023-02-20 /pmc/articles/PMC9951993/ /pubmed/36830088 http://dx.doi.org/10.3390/antiox12020530 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Valor, Diego Montes, Antonio Calderón-Domínguez, María Aghziel, Inass Sánchez-Gomar, Ismael Alcalá, Martín Durán-Ruiz, Ma Carmen Pereyra, Clara Generation of Highly Antioxidant Submicron Particles from Myrtus communis Leaf Extract by Supercritical Antisolvent Extraction Process |
title | Generation of Highly Antioxidant Submicron Particles from Myrtus communis Leaf Extract by Supercritical Antisolvent Extraction Process |
title_full | Generation of Highly Antioxidant Submicron Particles from Myrtus communis Leaf Extract by Supercritical Antisolvent Extraction Process |
title_fullStr | Generation of Highly Antioxidant Submicron Particles from Myrtus communis Leaf Extract by Supercritical Antisolvent Extraction Process |
title_full_unstemmed | Generation of Highly Antioxidant Submicron Particles from Myrtus communis Leaf Extract by Supercritical Antisolvent Extraction Process |
title_short | Generation of Highly Antioxidant Submicron Particles from Myrtus communis Leaf Extract by Supercritical Antisolvent Extraction Process |
title_sort | generation of highly antioxidant submicron particles from myrtus communis leaf extract by supercritical antisolvent extraction process |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951993/ https://www.ncbi.nlm.nih.gov/pubmed/36830088 http://dx.doi.org/10.3390/antiox12020530 |
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