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Phytochemical Profile and Biological Activities of Different Extracts of Three Parts of Paliurus spina-christi: A Linkage between Structure and Ability

Paliurus spina-christi Mill., a member of the Rhamnaceae family, is a traditionally used medicinal plant in the management of a panoply of human ailments. The current research focused on its phytochemical profile and biological properties evaluated by its antioxidant and enzyme inhibitory properties...

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Autores principales: Zengin, Gokhan, Fernández-Ochoa, Álvaro, Cádiz-Gurrea, María de la Luz, Leyva-Jiménez, Francisco Javier, Segura-Carretero, Antonio, Elbasan, Fevzi, Yildiztugay, Evren, Malik, Sumira, Khalid, Asaad, Abdalla, Ashraf N., Fawzi Mahomoodally, Mohamad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952067/
https://www.ncbi.nlm.nih.gov/pubmed/36829813
http://dx.doi.org/10.3390/antiox12020255
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author Zengin, Gokhan
Fernández-Ochoa, Álvaro
Cádiz-Gurrea, María de la Luz
Leyva-Jiménez, Francisco Javier
Segura-Carretero, Antonio
Elbasan, Fevzi
Yildiztugay, Evren
Malik, Sumira
Khalid, Asaad
Abdalla, Ashraf N.
Fawzi Mahomoodally, Mohamad
author_facet Zengin, Gokhan
Fernández-Ochoa, Álvaro
Cádiz-Gurrea, María de la Luz
Leyva-Jiménez, Francisco Javier
Segura-Carretero, Antonio
Elbasan, Fevzi
Yildiztugay, Evren
Malik, Sumira
Khalid, Asaad
Abdalla, Ashraf N.
Fawzi Mahomoodally, Mohamad
author_sort Zengin, Gokhan
collection PubMed
description Paliurus spina-christi Mill., a member of the Rhamnaceae family, is a traditionally used medicinal plant in the management of a panoply of human ailments. The current research focused on its phytochemical profile and biological properties evaluated by its antioxidant and enzyme inhibitory properties. The methanol extract was found to be the most effective antioxidant as evidenced by its DPPH and ABTS scavenging activities, cupric and ferric reducing power (CUPRAC and FRAP), and high activity in phosphomolybdenum (PBD) assay, and also displayed the highest anti-tyrosinase activity. The n-hexane extract was the most effective AChE inhibitor (8.89 ± 0.08 mg GALAE/g) followed by the methanol (8.64 ± 0.01 mg GALAE/g) while the latter showed the highest BChE inhibition (2.50 ± 0.05 mg GALAE/g). Among the different solvent extracts of the stem, the methanolic extract showed highest antioxidant activity in the following assays: DPPH (909.88 ± 4.25 mg TE/g), ABTS (3358.33 ± 51.14 mg TE/g), CUPRAC (781.88 ± 16.37 mg TE/g), FRAP (996.70 ± 47.28 mg TE/g), and PBD (4.96 ± 0.26 mmol TE/g), while the dichloromethane extract showed the highest MCA (28.80 ± 0.32 mg EDTAE/g). The methanol extracts revealed the highest TPC and TFC among the different solvents used, and as for plant part, the stem extracts had the highest TPC ranging from 22.36 ± 0.26 to 121.78 ± 1.41 (mg GAE/g), while the leaf extracts showed the highest TFC ranging from 8.43 ± 0.03 to 75.36 ± 0.92 (mg RE/g). Our findings tend to provide additional scientific evidence on the biological and chemical activities of P. spina-christi, which may serve as a source of naturally occurring bioactive chemicals with potential biomedical applications.
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spelling pubmed-99520672023-02-25 Phytochemical Profile and Biological Activities of Different Extracts of Three Parts of Paliurus spina-christi: A Linkage between Structure and Ability Zengin, Gokhan Fernández-Ochoa, Álvaro Cádiz-Gurrea, María de la Luz Leyva-Jiménez, Francisco Javier Segura-Carretero, Antonio Elbasan, Fevzi Yildiztugay, Evren Malik, Sumira Khalid, Asaad Abdalla, Ashraf N. Fawzi Mahomoodally, Mohamad Antioxidants (Basel) Article Paliurus spina-christi Mill., a member of the Rhamnaceae family, is a traditionally used medicinal plant in the management of a panoply of human ailments. The current research focused on its phytochemical profile and biological properties evaluated by its antioxidant and enzyme inhibitory properties. The methanol extract was found to be the most effective antioxidant as evidenced by its DPPH and ABTS scavenging activities, cupric and ferric reducing power (CUPRAC and FRAP), and high activity in phosphomolybdenum (PBD) assay, and also displayed the highest anti-tyrosinase activity. The n-hexane extract was the most effective AChE inhibitor (8.89 ± 0.08 mg GALAE/g) followed by the methanol (8.64 ± 0.01 mg GALAE/g) while the latter showed the highest BChE inhibition (2.50 ± 0.05 mg GALAE/g). Among the different solvent extracts of the stem, the methanolic extract showed highest antioxidant activity in the following assays: DPPH (909.88 ± 4.25 mg TE/g), ABTS (3358.33 ± 51.14 mg TE/g), CUPRAC (781.88 ± 16.37 mg TE/g), FRAP (996.70 ± 47.28 mg TE/g), and PBD (4.96 ± 0.26 mmol TE/g), while the dichloromethane extract showed the highest MCA (28.80 ± 0.32 mg EDTAE/g). The methanol extracts revealed the highest TPC and TFC among the different solvents used, and as for plant part, the stem extracts had the highest TPC ranging from 22.36 ± 0.26 to 121.78 ± 1.41 (mg GAE/g), while the leaf extracts showed the highest TFC ranging from 8.43 ± 0.03 to 75.36 ± 0.92 (mg RE/g). Our findings tend to provide additional scientific evidence on the biological and chemical activities of P. spina-christi, which may serve as a source of naturally occurring bioactive chemicals with potential biomedical applications. MDPI 2023-01-23 /pmc/articles/PMC9952067/ /pubmed/36829813 http://dx.doi.org/10.3390/antiox12020255 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zengin, Gokhan
Fernández-Ochoa, Álvaro
Cádiz-Gurrea, María de la Luz
Leyva-Jiménez, Francisco Javier
Segura-Carretero, Antonio
Elbasan, Fevzi
Yildiztugay, Evren
Malik, Sumira
Khalid, Asaad
Abdalla, Ashraf N.
Fawzi Mahomoodally, Mohamad
Phytochemical Profile and Biological Activities of Different Extracts of Three Parts of Paliurus spina-christi: A Linkage between Structure and Ability
title Phytochemical Profile and Biological Activities of Different Extracts of Three Parts of Paliurus spina-christi: A Linkage between Structure and Ability
title_full Phytochemical Profile and Biological Activities of Different Extracts of Three Parts of Paliurus spina-christi: A Linkage between Structure and Ability
title_fullStr Phytochemical Profile and Biological Activities of Different Extracts of Three Parts of Paliurus spina-christi: A Linkage between Structure and Ability
title_full_unstemmed Phytochemical Profile and Biological Activities of Different Extracts of Three Parts of Paliurus spina-christi: A Linkage between Structure and Ability
title_short Phytochemical Profile and Biological Activities of Different Extracts of Three Parts of Paliurus spina-christi: A Linkage between Structure and Ability
title_sort phytochemical profile and biological activities of different extracts of three parts of paliurus spina-christi: a linkage between structure and ability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952067/
https://www.ncbi.nlm.nih.gov/pubmed/36829813
http://dx.doi.org/10.3390/antiox12020255
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