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Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs
Oxylipins are important biological molecules with diverse roles in human and plants such as pro-/anti-inflammatory, antimicrobial, and regulatory activity. Although there is an increasing number of plant-derived oxylipins, most of their physiological roles in humans remain unclear. Here, we describe...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952087/ https://www.ncbi.nlm.nih.gov/pubmed/36829842 http://dx.doi.org/10.3390/antiox12020284 |
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author | Lee, Da Yeong Park, Kyoung Jin Subedi, Lalita Lee, Gyu Sung Lee, Ji-Hyeok Lee, Won-Min Choi, Sang Un Hong, Seong-Min Kim, Sun Yeou Kim, Chung Sub |
author_facet | Lee, Da Yeong Park, Kyoung Jin Subedi, Lalita Lee, Gyu Sung Lee, Ji-Hyeok Lee, Won-Min Choi, Sang Un Hong, Seong-Min Kim, Sun Yeou Kim, Chung Sub |
author_sort | Lee, Da Yeong |
collection | PubMed |
description | Oxylipins are important biological molecules with diverse roles in human and plants such as pro-/anti-inflammatory, antimicrobial, and regulatory activity. Although there is an increasing number of plant-derived oxylipins, most of their physiological roles in humans remain unclear. Here, we describe the isolation, identification, and biological activities of four new oxylipins, chaenomesters A–D (1–4), along with a known compound (5), obtained from Chaenomeles sinensis twigs. Their chemical structures were determined by spectroscopic (i.e., NMR) and spectrometric (i.e., HRMS) data analysis including (1)H NMR-based empirical rules and homonuclear-decoupled (1)H NMR experiments. Chaenomester D (4), an omega-3 oxylipin, showed a potent inhibitory effect on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells (NO production, 8.46 ± 0.68 μM), neurotrophic activity in C6 cells through the induction of the secretion of nerve growth factor (NGF, 157.7 ± 2.4%), and cytotoxicity in A549 human cancer cell lines (IC(50) = 27.4 μM). |
format | Online Article Text |
id | pubmed-9952087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99520872023-02-25 Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs Lee, Da Yeong Park, Kyoung Jin Subedi, Lalita Lee, Gyu Sung Lee, Ji-Hyeok Lee, Won-Min Choi, Sang Un Hong, Seong-Min Kim, Sun Yeou Kim, Chung Sub Antioxidants (Basel) Article Oxylipins are important biological molecules with diverse roles in human and plants such as pro-/anti-inflammatory, antimicrobial, and regulatory activity. Although there is an increasing number of plant-derived oxylipins, most of their physiological roles in humans remain unclear. Here, we describe the isolation, identification, and biological activities of four new oxylipins, chaenomesters A–D (1–4), along with a known compound (5), obtained from Chaenomeles sinensis twigs. Their chemical structures were determined by spectroscopic (i.e., NMR) and spectrometric (i.e., HRMS) data analysis including (1)H NMR-based empirical rules and homonuclear-decoupled (1)H NMR experiments. Chaenomester D (4), an omega-3 oxylipin, showed a potent inhibitory effect on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells (NO production, 8.46 ± 0.68 μM), neurotrophic activity in C6 cells through the induction of the secretion of nerve growth factor (NGF, 157.7 ± 2.4%), and cytotoxicity in A549 human cancer cell lines (IC(50) = 27.4 μM). MDPI 2023-01-27 /pmc/articles/PMC9952087/ /pubmed/36829842 http://dx.doi.org/10.3390/antiox12020284 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Da Yeong Park, Kyoung Jin Subedi, Lalita Lee, Gyu Sung Lee, Ji-Hyeok Lee, Won-Min Choi, Sang Un Hong, Seong-Min Kim, Sun Yeou Kim, Chung Sub Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs |
title | Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs |
title_full | Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs |
title_fullStr | Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs |
title_full_unstemmed | Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs |
title_short | Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs |
title_sort | anti-inflammatory, neurotrophic, and cytotoxic oxylipins isolated from chaenomeles sinensis twigs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952087/ https://www.ncbi.nlm.nih.gov/pubmed/36829842 http://dx.doi.org/10.3390/antiox12020284 |
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