Cargando…
Evaluating Hydroxyapatite, Gold Nanoparticles, and Graphene-Copper as Bimodal Agents for X-ray and Computed Tomography
A global need exists for new and more effective contrast agents for computed tomography and traditional X-ray modalities. Among the few options available nowadays, limitations imposed by industrial production, performance, and efficacy restrict the use and reduce the potential of both imaging techni...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952155/ https://www.ncbi.nlm.nih.gov/pubmed/36829732 http://dx.doi.org/10.3390/bioengineering10020238 |
_version_ | 1784893560597774336 |
---|---|
author | Pugliese Pereira, Bruno Antoine, Claudia de Barros, Aline Oliveira da Silva Pacífico, Leonardo de Castro Pijeira, Martha Sahylí Ortega Rossi, Alexandre Malta Ricci-Junior, Eduardo Alencar, Luciana Magalhães Rebelo Santos-Oliveira, Ralph |
author_facet | Pugliese Pereira, Bruno Antoine, Claudia de Barros, Aline Oliveira da Silva Pacífico, Leonardo de Castro Pijeira, Martha Sahylí Ortega Rossi, Alexandre Malta Ricci-Junior, Eduardo Alencar, Luciana Magalhães Rebelo Santos-Oliveira, Ralph |
author_sort | Pugliese Pereira, Bruno |
collection | PubMed |
description | A global need exists for new and more effective contrast agents for computed tomography and traditional X-ray modalities. Among the few options available nowadays, limitations imposed by industrial production, performance, and efficacy restrict the use and reduce the potential of both imaging techniques. The use of nanomaterials as new contrast agents for X-ray and computed tomography is an innovative and viable way to increase the options and enhance performance. In this study, we evaluated eight nanomaterials: hydroxyapatite doped with zinc (Zn-HA 10%); hydroxyapatite doped with strontium (Sr-HA 10%); hydroxyapatite without thermal treatment (HA 282 STT); thermally treated hydroxyapatite (HA 212 500 °C and HA 01.256 CTT 1000 °C); hydroxyapatite microspheres (HA microspheres); gold nanoparticles (AuNP); and graphene oxide doped with copper (Cu-GO). The results showed that for both imaging modalities; HA microspheres were the best option, followed by hydroxyapatite thermally treated at 1000 °C. The nanomaterials with the worst results were hydroxyapatite doped with zinc (Zn-HA 10%), and hydroxyapatite doped with strontium (Sr-HA 10%). Our data demonstrated the potential of using nanomaterials, especially HA microspheres, and hydroxyapatite with thermal treatment (HA 01.256 CTT 1000 °C) as contrast agents for X-ray and computed tomography. |
format | Online Article Text |
id | pubmed-9952155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99521552023-02-25 Evaluating Hydroxyapatite, Gold Nanoparticles, and Graphene-Copper as Bimodal Agents for X-ray and Computed Tomography Pugliese Pereira, Bruno Antoine, Claudia de Barros, Aline Oliveira da Silva Pacífico, Leonardo de Castro Pijeira, Martha Sahylí Ortega Rossi, Alexandre Malta Ricci-Junior, Eduardo Alencar, Luciana Magalhães Rebelo Santos-Oliveira, Ralph Bioengineering (Basel) Brief Report A global need exists for new and more effective contrast agents for computed tomography and traditional X-ray modalities. Among the few options available nowadays, limitations imposed by industrial production, performance, and efficacy restrict the use and reduce the potential of both imaging techniques. The use of nanomaterials as new contrast agents for X-ray and computed tomography is an innovative and viable way to increase the options and enhance performance. In this study, we evaluated eight nanomaterials: hydroxyapatite doped with zinc (Zn-HA 10%); hydroxyapatite doped with strontium (Sr-HA 10%); hydroxyapatite without thermal treatment (HA 282 STT); thermally treated hydroxyapatite (HA 212 500 °C and HA 01.256 CTT 1000 °C); hydroxyapatite microspheres (HA microspheres); gold nanoparticles (AuNP); and graphene oxide doped with copper (Cu-GO). The results showed that for both imaging modalities; HA microspheres were the best option, followed by hydroxyapatite thermally treated at 1000 °C. The nanomaterials with the worst results were hydroxyapatite doped with zinc (Zn-HA 10%), and hydroxyapatite doped with strontium (Sr-HA 10%). Our data demonstrated the potential of using nanomaterials, especially HA microspheres, and hydroxyapatite with thermal treatment (HA 01.256 CTT 1000 °C) as contrast agents for X-ray and computed tomography. MDPI 2023-02-10 /pmc/articles/PMC9952155/ /pubmed/36829732 http://dx.doi.org/10.3390/bioengineering10020238 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Pugliese Pereira, Bruno Antoine, Claudia de Barros, Aline Oliveira da Silva Pacífico, Leonardo de Castro Pijeira, Martha Sahylí Ortega Rossi, Alexandre Malta Ricci-Junior, Eduardo Alencar, Luciana Magalhães Rebelo Santos-Oliveira, Ralph Evaluating Hydroxyapatite, Gold Nanoparticles, and Graphene-Copper as Bimodal Agents for X-ray and Computed Tomography |
title | Evaluating Hydroxyapatite, Gold Nanoparticles, and Graphene-Copper as Bimodal Agents for X-ray and Computed Tomography |
title_full | Evaluating Hydroxyapatite, Gold Nanoparticles, and Graphene-Copper as Bimodal Agents for X-ray and Computed Tomography |
title_fullStr | Evaluating Hydroxyapatite, Gold Nanoparticles, and Graphene-Copper as Bimodal Agents for X-ray and Computed Tomography |
title_full_unstemmed | Evaluating Hydroxyapatite, Gold Nanoparticles, and Graphene-Copper as Bimodal Agents for X-ray and Computed Tomography |
title_short | Evaluating Hydroxyapatite, Gold Nanoparticles, and Graphene-Copper as Bimodal Agents for X-ray and Computed Tomography |
title_sort | evaluating hydroxyapatite, gold nanoparticles, and graphene-copper as bimodal agents for x-ray and computed tomography |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952155/ https://www.ncbi.nlm.nih.gov/pubmed/36829732 http://dx.doi.org/10.3390/bioengineering10020238 |
work_keys_str_mv | AT pugliesepereirabruno evaluatinghydroxyapatitegoldnanoparticlesandgraphenecopperasbimodalagentsforxrayandcomputedtomography AT antoineclaudia evaluatinghydroxyapatitegoldnanoparticlesandgraphenecopperasbimodalagentsforxrayandcomputedtomography AT debarrosalineoliveiradasilva evaluatinghydroxyapatitegoldnanoparticlesandgraphenecopperasbimodalagentsforxrayandcomputedtomography AT pacificoleonardodecastro evaluatinghydroxyapatitegoldnanoparticlesandgraphenecopperasbimodalagentsforxrayandcomputedtomography AT pijeiramarthasahyliortega evaluatinghydroxyapatitegoldnanoparticlesandgraphenecopperasbimodalagentsforxrayandcomputedtomography AT rossialexandremalta evaluatinghydroxyapatitegoldnanoparticlesandgraphenecopperasbimodalagentsforxrayandcomputedtomography AT riccijunioreduardo evaluatinghydroxyapatitegoldnanoparticlesandgraphenecopperasbimodalagentsforxrayandcomputedtomography AT alencarlucianamagalhaesrebelo evaluatinghydroxyapatitegoldnanoparticlesandgraphenecopperasbimodalagentsforxrayandcomputedtomography AT santosoliveiraralph evaluatinghydroxyapatitegoldnanoparticlesandgraphenecopperasbimodalagentsforxrayandcomputedtomography |