Fatal Epileptic Seizures in Mice Having Compromised Glutathione and Ascorbic Acid Biosynthesis

Reduced glutathione (GSH) and ascorbic acid (AA) are the two most abundant low-molecular-weight antioxidants in mammalian tissues. Gclm(KO) knockout mice lack the gene encoding the modifier subunit of the rate-limiting enzyme in GSH biosynthesis; Gclm(KO) mice exhibit 10–40% of normal tissue GSH lev...

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Detalles Bibliográficos
Autores principales: Chen, Ying, Holland, Katherine D., Shertzer, Howard G., Nebert, Daniel W., Dalton, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952205/
https://www.ncbi.nlm.nih.gov/pubmed/36830006
http://dx.doi.org/10.3390/antiox12020448

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