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The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus

The ESKAPEE bacterial pathogen Staphylococcus aureus has posed a serious public health concern for centuries. Throughout its evolutionary course, S. aureus has developed strains with resistance to antimicrobial agents. The bacterial pathogen has acquired multidrug resistance, causing, in many cases,...

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Detalles Bibliográficos
Autores principales: Stephen, Jerusha, Salam, Fathima, Lekshmi, Manjusha, Kumar, Sanath H., Varela, Manuel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952236/
https://www.ncbi.nlm.nih.gov/pubmed/36830254
http://dx.doi.org/10.3390/antibiotics12020343
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author Stephen, Jerusha
Salam, Fathima
Lekshmi, Manjusha
Kumar, Sanath H.
Varela, Manuel F.
author_facet Stephen, Jerusha
Salam, Fathima
Lekshmi, Manjusha
Kumar, Sanath H.
Varela, Manuel F.
author_sort Stephen, Jerusha
collection PubMed
description The ESKAPEE bacterial pathogen Staphylococcus aureus has posed a serious public health concern for centuries. Throughout its evolutionary course, S. aureus has developed strains with resistance to antimicrobial agents. The bacterial pathogen has acquired multidrug resistance, causing, in many cases, untreatable infectious diseases and raising serious public safety and healthcare concerns. Amongst the various mechanisms for antimicrobial resistance, integral membrane proteins that serve as secondary active transporters from the major facilitator superfamily constitute a chief system of multidrug resistance. These MFS transporters actively export structurally different antimicrobial agents from the cells of S. aureus. This review article discusses the S. aureus-specific MFS multidrug efflux pump systems from a molecular mechanistic perspective, paying particular attention to structure–function relationships, modulation of antimicrobial resistance mediated by MFS drug efflux pumps, and direction for future investigation.
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spelling pubmed-99522362023-02-25 The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus Stephen, Jerusha Salam, Fathima Lekshmi, Manjusha Kumar, Sanath H. Varela, Manuel F. Antibiotics (Basel) Review The ESKAPEE bacterial pathogen Staphylococcus aureus has posed a serious public health concern for centuries. Throughout its evolutionary course, S. aureus has developed strains with resistance to antimicrobial agents. The bacterial pathogen has acquired multidrug resistance, causing, in many cases, untreatable infectious diseases and raising serious public safety and healthcare concerns. Amongst the various mechanisms for antimicrobial resistance, integral membrane proteins that serve as secondary active transporters from the major facilitator superfamily constitute a chief system of multidrug resistance. These MFS transporters actively export structurally different antimicrobial agents from the cells of S. aureus. This review article discusses the S. aureus-specific MFS multidrug efflux pump systems from a molecular mechanistic perspective, paying particular attention to structure–function relationships, modulation of antimicrobial resistance mediated by MFS drug efflux pumps, and direction for future investigation. MDPI 2023-02-07 /pmc/articles/PMC9952236/ /pubmed/36830254 http://dx.doi.org/10.3390/antibiotics12020343 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stephen, Jerusha
Salam, Fathima
Lekshmi, Manjusha
Kumar, Sanath H.
Varela, Manuel F.
The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus
title The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus
title_full The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus
title_fullStr The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus
title_full_unstemmed The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus
title_short The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus
title_sort major facilitator superfamily and antimicrobial resistance efflux pumps of the eskapee pathogen staphylococcus aureus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952236/
https://www.ncbi.nlm.nih.gov/pubmed/36830254
http://dx.doi.org/10.3390/antibiotics12020343
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