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Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure

Background: Metabolic syndrome (MetS) and chronic kidney disease (CKD) are commonly associated with cardiovascular disease (CVD) and in these patients Mg concentration is usually decreased. This study evaluated whether a dietary Mg supplementation might attenuate vascular dysfunction through the mod...

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Autores principales: López-Baltanás, Rodrigo, Rodríguez-Ortiz, María E., Díaz-Tocados, Juan M., Martinez-Moreno, Julio M., Membrives, Cristina, Rodelo-Haad, Cristian, Pendón Ruiz de Mier, M. Victoria, Rodríguez, Mariano, Canalejo, Antonio, Almadén, Yolanda, Muñoz-Castañeda, Juan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952257/
https://www.ncbi.nlm.nih.gov/pubmed/36829843
http://dx.doi.org/10.3390/antiox12020283
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author López-Baltanás, Rodrigo
Rodríguez-Ortiz, María E.
Díaz-Tocados, Juan M.
Martinez-Moreno, Julio M.
Membrives, Cristina
Rodelo-Haad, Cristian
Pendón Ruiz de Mier, M. Victoria
Rodríguez, Mariano
Canalejo, Antonio
Almadén, Yolanda
Muñoz-Castañeda, Juan R.
author_facet López-Baltanás, Rodrigo
Rodríguez-Ortiz, María E.
Díaz-Tocados, Juan M.
Martinez-Moreno, Julio M.
Membrives, Cristina
Rodelo-Haad, Cristian
Pendón Ruiz de Mier, M. Victoria
Rodríguez, Mariano
Canalejo, Antonio
Almadén, Yolanda
Muñoz-Castañeda, Juan R.
author_sort López-Baltanás, Rodrigo
collection PubMed
description Background: Metabolic syndrome (MetS) and chronic kidney disease (CKD) are commonly associated with cardiovascular disease (CVD) and in these patients Mg concentration is usually decreased. This study evaluated whether a dietary Mg supplementation might attenuate vascular dysfunction through the modulation of oxidative stress and inflammation in concurrent MetS and CKD. Methods: A rat model of MetS (Zucker strain) with CKD (5/6 nephrectomy, Nx) was used. Nephrectomized animals were fed a normal 0.1%Mg (MetS+Nx+Mg0.1%) or a supplemented 0.6%Mg (MetS+Nx+Mg0.6%) diet; Sham-operated rats with MetS receiving 0.1%Mg were used as controls. Results: As compared to controls, the MetS+Nx-Mg0.1% group showed a significant increase in oxidative stress and inflammation biomarkers (lipid peroxidation and aortic interleukin-1b and -6 expression) and Endothelin-1 levels, a decrease in nitric oxide and a worsening in uremia and MetS associated pathology as hypertension, and abnormal glucose and lipid profile. Moreover, proteomic evaluation revealed changes mainly related to lipid metabolism and CVD markers. By contrast, in the MetS+Nx+Mg0.6% group, these parameters remained largely similar to controls. Conclusion: In concurrent MetS and CKD, dietary Mg supplementation reduced inflammation and oxidative stress and improved vascular function.
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spelling pubmed-99522572023-02-25 Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure López-Baltanás, Rodrigo Rodríguez-Ortiz, María E. Díaz-Tocados, Juan M. Martinez-Moreno, Julio M. Membrives, Cristina Rodelo-Haad, Cristian Pendón Ruiz de Mier, M. Victoria Rodríguez, Mariano Canalejo, Antonio Almadén, Yolanda Muñoz-Castañeda, Juan R. Antioxidants (Basel) Article Background: Metabolic syndrome (MetS) and chronic kidney disease (CKD) are commonly associated with cardiovascular disease (CVD) and in these patients Mg concentration is usually decreased. This study evaluated whether a dietary Mg supplementation might attenuate vascular dysfunction through the modulation of oxidative stress and inflammation in concurrent MetS and CKD. Methods: A rat model of MetS (Zucker strain) with CKD (5/6 nephrectomy, Nx) was used. Nephrectomized animals were fed a normal 0.1%Mg (MetS+Nx+Mg0.1%) or a supplemented 0.6%Mg (MetS+Nx+Mg0.6%) diet; Sham-operated rats with MetS receiving 0.1%Mg were used as controls. Results: As compared to controls, the MetS+Nx-Mg0.1% group showed a significant increase in oxidative stress and inflammation biomarkers (lipid peroxidation and aortic interleukin-1b and -6 expression) and Endothelin-1 levels, a decrease in nitric oxide and a worsening in uremia and MetS associated pathology as hypertension, and abnormal glucose and lipid profile. Moreover, proteomic evaluation revealed changes mainly related to lipid metabolism and CVD markers. By contrast, in the MetS+Nx+Mg0.6% group, these parameters remained largely similar to controls. Conclusion: In concurrent MetS and CKD, dietary Mg supplementation reduced inflammation and oxidative stress and improved vascular function. MDPI 2023-01-27 /pmc/articles/PMC9952257/ /pubmed/36829843 http://dx.doi.org/10.3390/antiox12020283 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
López-Baltanás, Rodrigo
Rodríguez-Ortiz, María E.
Díaz-Tocados, Juan M.
Martinez-Moreno, Julio M.
Membrives, Cristina
Rodelo-Haad, Cristian
Pendón Ruiz de Mier, M. Victoria
Rodríguez, Mariano
Canalejo, Antonio
Almadén, Yolanda
Muñoz-Castañeda, Juan R.
Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure
title Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure
title_full Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure
title_fullStr Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure
title_full_unstemmed Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure
title_short Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure
title_sort dietary mg supplementation decreases oxidative stress, inflammation, and vascular dysfunction in an experimental model of metabolic syndrome with renal failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952257/
https://www.ncbi.nlm.nih.gov/pubmed/36829843
http://dx.doi.org/10.3390/antiox12020283
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