De Novo Design of Imidazopyridine-Tethered Pyrazolines That Target Phosphorylation of STAT3 in Human Breast Cancer Cells

In breast cancer (BC), STAT3 is hyperactivated. This study explored the design of imidazopyridine-tethered pyrazolines as a de novo drug strategy for inhibiting STAT3 phosphorylation in human BC cells. This involved the synthesis and characterization of two series of compounds namely, 1-(3-(2,6-dime...

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Detalles Bibliográficos
Autores principales: Ravish, Akshay, Shivakumar, Rashmi, Xi, Zhang, Yang, Min Hee, Yang, Ji-Rui, Swamynayaka, Ananda, Nagaraja, Omantheswara, Madegowda, Mahendra, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Pandey, Vijay, Sethi, Gautam, Ahn, Kwang Seok, Lobie, Peter E., Basappa, Basappa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952374/
https://www.ncbi.nlm.nih.gov/pubmed/36829653
http://dx.doi.org/10.3390/bioengineering10020159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952374/
https://www.ncbi.nlm.nih.gov/pubmed/36829653
http://dx.doi.org/10.3390/bioengineering10020159

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