CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD(+)-Lowering Agents

Cancer cells fuel growth and energy demands by increasing their NAD(+) biosynthesis dependency, which therefore represents an exploitable vulnerability for anti-cancer strategies. CD38 is a NAD(+)-degrading enzyme that has become crucial for anti-MM therapies since anti-CD38 monoclonal antibodies re...

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Detalles Bibliográficos
Autores principales: Becherini, Pamela, Soncini, Debora, Ravera, Silvia, Gelli, Elisa, Martinuzzi, Claudia, Giorgetti, Giulia, Cagnetta, Antonia, Guolo, Fabio, Ivaldi, Federico, Miglino, Maurizio, Aquino, Sara, Todoerti, Katia, Neri, Antonino, Benzi, Andrea, Passalacqua, Mario, Nencioni, Alessio, Perrotta, Ida, Gallo Cantafio, Maria Eugenia, Amodio, Nicola, De Flora, Antonio, Bruzzone, Santina, Lemoli, Roberto M., Cea, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952390/
https://www.ncbi.nlm.nih.gov/pubmed/36830052
http://dx.doi.org/10.3390/antiox12020494

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