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Extracellular Vesicles as Regulators of the Extracellular Matrix
Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EV...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952427/ https://www.ncbi.nlm.nih.gov/pubmed/36829629 http://dx.doi.org/10.3390/bioengineering10020136 |
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author | Patel, Neil J. Ashraf, Anisa Chung, Eun Ji |
author_facet | Patel, Neil J. Ashraf, Anisa Chung, Eun Ji |
author_sort | Patel, Neil J. |
collection | PubMed |
description | Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EVs interact with the extracellular matrix (ECM) which acts as a physical scaffold for the organization and function of cells. Recent work has shown that EVs can modulate and act as regulators of the ECM. This review will first discuss EV biogenesis and the mechanism by which EVs are transported through the ECM. Additionally, we discuss how EVs contribute as structural components of the matrix and as components that aid in the degradation of the ECM. Lastly, the role of EVs in influencing recipient cells to remodel the ECM in both pathological and therapeutic contexts is examined. |
format | Online Article Text |
id | pubmed-9952427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99524272023-02-25 Extracellular Vesicles as Regulators of the Extracellular Matrix Patel, Neil J. Ashraf, Anisa Chung, Eun Ji Bioengineering (Basel) Review Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EVs interact with the extracellular matrix (ECM) which acts as a physical scaffold for the organization and function of cells. Recent work has shown that EVs can modulate and act as regulators of the ECM. This review will first discuss EV biogenesis and the mechanism by which EVs are transported through the ECM. Additionally, we discuss how EVs contribute as structural components of the matrix and as components that aid in the degradation of the ECM. Lastly, the role of EVs in influencing recipient cells to remodel the ECM in both pathological and therapeutic contexts is examined. MDPI 2023-01-19 /pmc/articles/PMC9952427/ /pubmed/36829629 http://dx.doi.org/10.3390/bioengineering10020136 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Patel, Neil J. Ashraf, Anisa Chung, Eun Ji Extracellular Vesicles as Regulators of the Extracellular Matrix |
title | Extracellular Vesicles as Regulators of the Extracellular Matrix |
title_full | Extracellular Vesicles as Regulators of the Extracellular Matrix |
title_fullStr | Extracellular Vesicles as Regulators of the Extracellular Matrix |
title_full_unstemmed | Extracellular Vesicles as Regulators of the Extracellular Matrix |
title_short | Extracellular Vesicles as Regulators of the Extracellular Matrix |
title_sort | extracellular vesicles as regulators of the extracellular matrix |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952427/ https://www.ncbi.nlm.nih.gov/pubmed/36829629 http://dx.doi.org/10.3390/bioengineering10020136 |
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