Cargando…

Extracellular Vesicles as Regulators of the Extracellular Matrix

Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EV...

Descripción completa

Detalles Bibliográficos
Autores principales: Patel, Neil J., Ashraf, Anisa, Chung, Eun Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952427/
https://www.ncbi.nlm.nih.gov/pubmed/36829629
http://dx.doi.org/10.3390/bioengineering10020136
_version_ 1784893628715368448
author Patel, Neil J.
Ashraf, Anisa
Chung, Eun Ji
author_facet Patel, Neil J.
Ashraf, Anisa
Chung, Eun Ji
author_sort Patel, Neil J.
collection PubMed
description Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EVs interact with the extracellular matrix (ECM) which acts as a physical scaffold for the organization and function of cells. Recent work has shown that EVs can modulate and act as regulators of the ECM. This review will first discuss EV biogenesis and the mechanism by which EVs are transported through the ECM. Additionally, we discuss how EVs contribute as structural components of the matrix and as components that aid in the degradation of the ECM. Lastly, the role of EVs in influencing recipient cells to remodel the ECM in both pathological and therapeutic contexts is examined.
format Online
Article
Text
id pubmed-9952427
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99524272023-02-25 Extracellular Vesicles as Regulators of the Extracellular Matrix Patel, Neil J. Ashraf, Anisa Chung, Eun Ji Bioengineering (Basel) Review Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EVs interact with the extracellular matrix (ECM) which acts as a physical scaffold for the organization and function of cells. Recent work has shown that EVs can modulate and act as regulators of the ECM. This review will first discuss EV biogenesis and the mechanism by which EVs are transported through the ECM. Additionally, we discuss how EVs contribute as structural components of the matrix and as components that aid in the degradation of the ECM. Lastly, the role of EVs in influencing recipient cells to remodel the ECM in both pathological and therapeutic contexts is examined. MDPI 2023-01-19 /pmc/articles/PMC9952427/ /pubmed/36829629 http://dx.doi.org/10.3390/bioengineering10020136 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Patel, Neil J.
Ashraf, Anisa
Chung, Eun Ji
Extracellular Vesicles as Regulators of the Extracellular Matrix
title Extracellular Vesicles as Regulators of the Extracellular Matrix
title_full Extracellular Vesicles as Regulators of the Extracellular Matrix
title_fullStr Extracellular Vesicles as Regulators of the Extracellular Matrix
title_full_unstemmed Extracellular Vesicles as Regulators of the Extracellular Matrix
title_short Extracellular Vesicles as Regulators of the Extracellular Matrix
title_sort extracellular vesicles as regulators of the extracellular matrix
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952427/
https://www.ncbi.nlm.nih.gov/pubmed/36829629
http://dx.doi.org/10.3390/bioengineering10020136
work_keys_str_mv AT patelneilj extracellularvesiclesasregulatorsoftheextracellularmatrix
AT ashrafanisa extracellularvesiclesasregulatorsoftheextracellularmatrix
AT chungeunji extracellularvesiclesasregulatorsoftheextracellularmatrix