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Computational Study of Hemodynamic Field of an Occluded Artery Model with Anastomosis

In this research work, the hemodynamic field of an occluded artery with anastomosis by means of computational simulation has been studied. The main objective of the current study is the investigation of 3D flow field phenomena in the by-pass region and the effect of the bypass graft to stenosis volu...

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Autores principales: Parissis, Panagiotis, Romeos, Alexandros, Giannadakis, Athanasios, Kalarakis, Alexandros, Peroulis, Michail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952429/
https://www.ncbi.nlm.nih.gov/pubmed/36829640
http://dx.doi.org/10.3390/bioengineering10020146
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author Parissis, Panagiotis
Romeos, Alexandros
Giannadakis, Athanasios
Kalarakis, Alexandros
Peroulis, Michail
author_facet Parissis, Panagiotis
Romeos, Alexandros
Giannadakis, Athanasios
Kalarakis, Alexandros
Peroulis, Michail
author_sort Parissis, Panagiotis
collection PubMed
description In this research work, the hemodynamic field of an occluded artery with anastomosis by means of computational simulation has been studied. The main objective of the current study is the investigation of 3D flow field phenomena in the by-pass region and the effect of the bypass graft to stenosis volume flow ratio on their formation. The anastomosis type was end-to-side with a 45° angle, while stenosis imposed a 75% area blockage of the aorta vessel and the total volume flow was 220 lt/h. The computational study of the flow field was utilized via a laminar flow model and three turbulence models (k—ε RNG, standard k—ω, and k—ω SST). Numerical results were compared qualitatively with experimental visualizations carried out under four different flow conditions, varying according to the flow ratio between the stenosis and the anastomotic graft. Comparison between computational results and experimental visualization findings exhibited a good agreement. Results showed that SST k—ω turbulence models reproduce better visually obtained flow patterns. Furthermore, cross-sectional velocity distributions demonstrated two distinct flow patterns down the bypass graft, depending on the flow ratio. Low values of flow ratio are characterized by fluid rolling up, whereas for high values fluid volume twisting was observed. Finally, areas with low wall shear stresses were mapped, as these are more prone to postoperative degradation of the bypass graft due to the development of subendothelial hyperplasia.
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spelling pubmed-99524292023-02-25 Computational Study of Hemodynamic Field of an Occluded Artery Model with Anastomosis Parissis, Panagiotis Romeos, Alexandros Giannadakis, Athanasios Kalarakis, Alexandros Peroulis, Michail Bioengineering (Basel) Article In this research work, the hemodynamic field of an occluded artery with anastomosis by means of computational simulation has been studied. The main objective of the current study is the investigation of 3D flow field phenomena in the by-pass region and the effect of the bypass graft to stenosis volume flow ratio on their formation. The anastomosis type was end-to-side with a 45° angle, while stenosis imposed a 75% area blockage of the aorta vessel and the total volume flow was 220 lt/h. The computational study of the flow field was utilized via a laminar flow model and three turbulence models (k—ε RNG, standard k—ω, and k—ω SST). Numerical results were compared qualitatively with experimental visualizations carried out under four different flow conditions, varying according to the flow ratio between the stenosis and the anastomotic graft. Comparison between computational results and experimental visualization findings exhibited a good agreement. Results showed that SST k—ω turbulence models reproduce better visually obtained flow patterns. Furthermore, cross-sectional velocity distributions demonstrated two distinct flow patterns down the bypass graft, depending on the flow ratio. Low values of flow ratio are characterized by fluid rolling up, whereas for high values fluid volume twisting was observed. Finally, areas with low wall shear stresses were mapped, as these are more prone to postoperative degradation of the bypass graft due to the development of subendothelial hyperplasia. MDPI 2023-01-21 /pmc/articles/PMC9952429/ /pubmed/36829640 http://dx.doi.org/10.3390/bioengineering10020146 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Parissis, Panagiotis
Romeos, Alexandros
Giannadakis, Athanasios
Kalarakis, Alexandros
Peroulis, Michail
Computational Study of Hemodynamic Field of an Occluded Artery Model with Anastomosis
title Computational Study of Hemodynamic Field of an Occluded Artery Model with Anastomosis
title_full Computational Study of Hemodynamic Field of an Occluded Artery Model with Anastomosis
title_fullStr Computational Study of Hemodynamic Field of an Occluded Artery Model with Anastomosis
title_full_unstemmed Computational Study of Hemodynamic Field of an Occluded Artery Model with Anastomosis
title_short Computational Study of Hemodynamic Field of an Occluded Artery Model with Anastomosis
title_sort computational study of hemodynamic field of an occluded artery model with anastomosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952429/
https://www.ncbi.nlm.nih.gov/pubmed/36829640
http://dx.doi.org/10.3390/bioengineering10020146
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