Cargando…
A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid
Linezolid (LZD) and Tedizolid (TZD) are oxazolidinone antibiotic for meticillin-resistant Staphylococcus aureus (MRSA). Severe hyponatremia after LZD administration have been reported. Severe hyponatremia cause seizures, unconsciousness, and even death. Therefore, we conducted a study to assess the...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952512/ https://www.ncbi.nlm.nih.gov/pubmed/36830256 http://dx.doi.org/10.3390/antibiotics12020345 |
_version_ | 1784893649909186560 |
---|---|
author | Shibata, Yuichi Hagihara, Mao Asai, Nobuhiro Shiota, Arufumi Hirai, Jun Mori, Nobuaki Mikamo, Hiroshige |
author_facet | Shibata, Yuichi Hagihara, Mao Asai, Nobuhiro Shiota, Arufumi Hirai, Jun Mori, Nobuaki Mikamo, Hiroshige |
author_sort | Shibata, Yuichi |
collection | PubMed |
description | Linezolid (LZD) and Tedizolid (TZD) are oxazolidinone antibiotic for meticillin-resistant Staphylococcus aureus (MRSA). Severe hyponatremia after LZD administration have been reported. Severe hyponatremia cause seizures, unconsciousness, and even death. Therefore, we conducted a study to assess the change of serum sodium level after LZD and TZD therapy. We enrolled 67 patients treated with LZD and 28 treated with TZD. We monitored the serum sodium level from the administration to 14 days after administration of oxazolidinone drug. Hyponatremia was defined a sodiuln level ≤134 mmol/L after the initiation of oxazolidinone drug. The frequency of hyponatremia in the LZD group was significantly higher than that in the TZD group (39.7% vs. 11.1%, p < 0.05). The rate of patients administered by injection was significantly higher than in the LZD group than in the TZD group (52.9% vs. 14.8%, p < 0.01). Multiple logistic regression analyses identified the albumin level before the oxazolidinone drug therapy as the independent variables associated with the development of hyponatremia. We revealed that TZD is safer than LZD in terms of hyponatremia. Therefore, cases that LZD is administered by injection should be used more carefully with hyponatremia in patients with low albumin level. |
format | Online Article Text |
id | pubmed-9952512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99525122023-02-25 A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid Shibata, Yuichi Hagihara, Mao Asai, Nobuhiro Shiota, Arufumi Hirai, Jun Mori, Nobuaki Mikamo, Hiroshige Antibiotics (Basel) Article Linezolid (LZD) and Tedizolid (TZD) are oxazolidinone antibiotic for meticillin-resistant Staphylococcus aureus (MRSA). Severe hyponatremia after LZD administration have been reported. Severe hyponatremia cause seizures, unconsciousness, and even death. Therefore, we conducted a study to assess the change of serum sodium level after LZD and TZD therapy. We enrolled 67 patients treated with LZD and 28 treated with TZD. We monitored the serum sodium level from the administration to 14 days after administration of oxazolidinone drug. Hyponatremia was defined a sodiuln level ≤134 mmol/L after the initiation of oxazolidinone drug. The frequency of hyponatremia in the LZD group was significantly higher than that in the TZD group (39.7% vs. 11.1%, p < 0.05). The rate of patients administered by injection was significantly higher than in the LZD group than in the TZD group (52.9% vs. 14.8%, p < 0.01). Multiple logistic regression analyses identified the albumin level before the oxazolidinone drug therapy as the independent variables associated with the development of hyponatremia. We revealed that TZD is safer than LZD in terms of hyponatremia. Therefore, cases that LZD is administered by injection should be used more carefully with hyponatremia in patients with low albumin level. MDPI 2023-02-07 /pmc/articles/PMC9952512/ /pubmed/36830256 http://dx.doi.org/10.3390/antibiotics12020345 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shibata, Yuichi Hagihara, Mao Asai, Nobuhiro Shiota, Arufumi Hirai, Jun Mori, Nobuaki Mikamo, Hiroshige A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid |
title | A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid |
title_full | A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid |
title_fullStr | A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid |
title_full_unstemmed | A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid |
title_short | A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid |
title_sort | retrospective study to compare the incidence of hyponatremia after administration between linezolid and tedizolid |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952512/ https://www.ncbi.nlm.nih.gov/pubmed/36830256 http://dx.doi.org/10.3390/antibiotics12020345 |
work_keys_str_mv | AT shibatayuichi aretrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT hagiharamao aretrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT asainobuhiro aretrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT shiotaarufumi aretrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT hiraijun aretrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT morinobuaki aretrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT mikamohiroshige aretrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT shibatayuichi retrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT hagiharamao retrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT asainobuhiro retrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT shiotaarufumi retrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT hiraijun retrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT morinobuaki retrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid AT mikamohiroshige retrospectivestudytocomparetheincidenceofhyponatremiaafteradministrationbetweenlinezolidandtedizolid |