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A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid

Linezolid (LZD) and Tedizolid (TZD) are oxazolidinone antibiotic for meticillin-resistant Staphylococcus aureus (MRSA). Severe hyponatremia after LZD administration have been reported. Severe hyponatremia cause seizures, unconsciousness, and even death. Therefore, we conducted a study to assess the...

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Autores principales: Shibata, Yuichi, Hagihara, Mao, Asai, Nobuhiro, Shiota, Arufumi, Hirai, Jun, Mori, Nobuaki, Mikamo, Hiroshige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952512/
https://www.ncbi.nlm.nih.gov/pubmed/36830256
http://dx.doi.org/10.3390/antibiotics12020345
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author Shibata, Yuichi
Hagihara, Mao
Asai, Nobuhiro
Shiota, Arufumi
Hirai, Jun
Mori, Nobuaki
Mikamo, Hiroshige
author_facet Shibata, Yuichi
Hagihara, Mao
Asai, Nobuhiro
Shiota, Arufumi
Hirai, Jun
Mori, Nobuaki
Mikamo, Hiroshige
author_sort Shibata, Yuichi
collection PubMed
description Linezolid (LZD) and Tedizolid (TZD) are oxazolidinone antibiotic for meticillin-resistant Staphylococcus aureus (MRSA). Severe hyponatremia after LZD administration have been reported. Severe hyponatremia cause seizures, unconsciousness, and even death. Therefore, we conducted a study to assess the change of serum sodium level after LZD and TZD therapy. We enrolled 67 patients treated with LZD and 28 treated with TZD. We monitored the serum sodium level from the administration to 14 days after administration of oxazolidinone drug. Hyponatremia was defined a sodiuln level ≤134 mmol/L after the initiation of oxazolidinone drug. The frequency of hyponatremia in the LZD group was significantly higher than that in the TZD group (39.7% vs. 11.1%, p < 0.05). The rate of patients administered by injection was significantly higher than in the LZD group than in the TZD group (52.9% vs. 14.8%, p < 0.01). Multiple logistic regression analyses identified the albumin level before the oxazolidinone drug therapy as the independent variables associated with the development of hyponatremia. We revealed that TZD is safer than LZD in terms of hyponatremia. Therefore, cases that LZD is administered by injection should be used more carefully with hyponatremia in patients with low albumin level.
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spelling pubmed-99525122023-02-25 A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid Shibata, Yuichi Hagihara, Mao Asai, Nobuhiro Shiota, Arufumi Hirai, Jun Mori, Nobuaki Mikamo, Hiroshige Antibiotics (Basel) Article Linezolid (LZD) and Tedizolid (TZD) are oxazolidinone antibiotic for meticillin-resistant Staphylococcus aureus (MRSA). Severe hyponatremia after LZD administration have been reported. Severe hyponatremia cause seizures, unconsciousness, and even death. Therefore, we conducted a study to assess the change of serum sodium level after LZD and TZD therapy. We enrolled 67 patients treated with LZD and 28 treated with TZD. We monitored the serum sodium level from the administration to 14 days after administration of oxazolidinone drug. Hyponatremia was defined a sodiuln level ≤134 mmol/L after the initiation of oxazolidinone drug. The frequency of hyponatremia in the LZD group was significantly higher than that in the TZD group (39.7% vs. 11.1%, p < 0.05). The rate of patients administered by injection was significantly higher than in the LZD group than in the TZD group (52.9% vs. 14.8%, p < 0.01). Multiple logistic regression analyses identified the albumin level before the oxazolidinone drug therapy as the independent variables associated with the development of hyponatremia. We revealed that TZD is safer than LZD in terms of hyponatremia. Therefore, cases that LZD is administered by injection should be used more carefully with hyponatremia in patients with low albumin level. MDPI 2023-02-07 /pmc/articles/PMC9952512/ /pubmed/36830256 http://dx.doi.org/10.3390/antibiotics12020345 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shibata, Yuichi
Hagihara, Mao
Asai, Nobuhiro
Shiota, Arufumi
Hirai, Jun
Mori, Nobuaki
Mikamo, Hiroshige
A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid
title A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid
title_full A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid
title_fullStr A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid
title_full_unstemmed A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid
title_short A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid
title_sort retrospective study to compare the incidence of hyponatremia after administration between linezolid and tedizolid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952512/
https://www.ncbi.nlm.nih.gov/pubmed/36830256
http://dx.doi.org/10.3390/antibiotics12020345
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