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Effects of Pulsed Radiofrequency Source on Cardiac Ablation

Heart arrhythmia is caused by abnormal electrical conduction through the myocardium, which in some cases, can be treated with heat. One of the challenges is to reduce temperature peaks—by still guaranteeing an efficient treatment where desired—to avoid any healthy tissue damage or any electrical iss...

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Autores principales: Iasiello, Marcello, Andreozzi, Assunta, Bianco, Nicola, Vafai, Kambiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952521/
https://www.ncbi.nlm.nih.gov/pubmed/36829721
http://dx.doi.org/10.3390/bioengineering10020227
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author Iasiello, Marcello
Andreozzi, Assunta
Bianco, Nicola
Vafai, Kambiz
author_facet Iasiello, Marcello
Andreozzi, Assunta
Bianco, Nicola
Vafai, Kambiz
author_sort Iasiello, Marcello
collection PubMed
description Heart arrhythmia is caused by abnormal electrical conduction through the myocardium, which in some cases, can be treated with heat. One of the challenges is to reduce temperature peaks—by still guaranteeing an efficient treatment where desired—to avoid any healthy tissue damage or any electrical issues within the device employed. A solution might be employing pulsed heat, in which thermal dose is given to the tissue with a variation in time. In this work, pulsed heat is used to modulate induced temperature fields during radiofrequency cardiac ablation. A three-dimensional model of the myocardium, catheter and blood flow is developed. Porous media, heat conduction and Navier–Stokes equations are, respectively, employed for each of the investigated domains. For the electric field, solved via Laplace equation, it is assumed that the electrode is at a fixed voltage. Pulsed heating effects are considered with a cosine time-variable pulsed function for the fixed voltage by constraining the product between this variable and time. Different dimensionless frequencies are considered and applied for different blood flow velocity and sustained voltages. Results are presented for different pulsed conditions to establish if a reasonable ablation zone, known from the obtained temperature profiles, can be obtained without any undesired temperature peaks.
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spelling pubmed-99525212023-02-25 Effects of Pulsed Radiofrequency Source on Cardiac Ablation Iasiello, Marcello Andreozzi, Assunta Bianco, Nicola Vafai, Kambiz Bioengineering (Basel) Article Heart arrhythmia is caused by abnormal electrical conduction through the myocardium, which in some cases, can be treated with heat. One of the challenges is to reduce temperature peaks—by still guaranteeing an efficient treatment where desired—to avoid any healthy tissue damage or any electrical issues within the device employed. A solution might be employing pulsed heat, in which thermal dose is given to the tissue with a variation in time. In this work, pulsed heat is used to modulate induced temperature fields during radiofrequency cardiac ablation. A three-dimensional model of the myocardium, catheter and blood flow is developed. Porous media, heat conduction and Navier–Stokes equations are, respectively, employed for each of the investigated domains. For the electric field, solved via Laplace equation, it is assumed that the electrode is at a fixed voltage. Pulsed heating effects are considered with a cosine time-variable pulsed function for the fixed voltage by constraining the product between this variable and time. Different dimensionless frequencies are considered and applied for different blood flow velocity and sustained voltages. Results are presented for different pulsed conditions to establish if a reasonable ablation zone, known from the obtained temperature profiles, can be obtained without any undesired temperature peaks. MDPI 2023-02-08 /pmc/articles/PMC9952521/ /pubmed/36829721 http://dx.doi.org/10.3390/bioengineering10020227 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iasiello, Marcello
Andreozzi, Assunta
Bianco, Nicola
Vafai, Kambiz
Effects of Pulsed Radiofrequency Source on Cardiac Ablation
title Effects of Pulsed Radiofrequency Source on Cardiac Ablation
title_full Effects of Pulsed Radiofrequency Source on Cardiac Ablation
title_fullStr Effects of Pulsed Radiofrequency Source on Cardiac Ablation
title_full_unstemmed Effects of Pulsed Radiofrequency Source on Cardiac Ablation
title_short Effects of Pulsed Radiofrequency Source on Cardiac Ablation
title_sort effects of pulsed radiofrequency source on cardiac ablation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952521/
https://www.ncbi.nlm.nih.gov/pubmed/36829721
http://dx.doi.org/10.3390/bioengineering10020227
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