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Design of an Automatically Controlled Multi-Axis Stretching Device for Mechanical Evaluations of the Anterior Eye Segment

The young eye has an accommodative ability involving lens shape changes to focus over different distances. This function gradually decreases with age, resulting in presbyopia. Greater insights into the mechanical properties of anterior eye structures can improve understanding of the causes of presby...

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Autores principales: Wang, Kehao, Qiu, Ziyan, Xie, Yiping, Cai, Shuo, Zhao, Yang, Pierscionek, Barbara K., Guo, Jiangzhen, Fan, Yubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952546/
https://www.ncbi.nlm.nih.gov/pubmed/36829636
http://dx.doi.org/10.3390/bioengineering10020142
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author Wang, Kehao
Qiu, Ziyan
Xie, Yiping
Cai, Shuo
Zhao, Yang
Pierscionek, Barbara K.
Guo, Jiangzhen
Fan, Yubo
author_facet Wang, Kehao
Qiu, Ziyan
Xie, Yiping
Cai, Shuo
Zhao, Yang
Pierscionek, Barbara K.
Guo, Jiangzhen
Fan, Yubo
author_sort Wang, Kehao
collection PubMed
description The young eye has an accommodative ability involving lens shape changes to focus over different distances. This function gradually decreases with age, resulting in presbyopia. Greater insights into the mechanical properties of anterior eye structures can improve understanding of the causes of presbyopia. The present study aims to develop a multi-axis stretching device for evaluating the mechanical properties of the intact eye lens. A stretching device integrating the mechanical stretcher, motor, torque sensor and data transmission mechanism was designed and developed by 3D printing. The mechanical stretcher can convert rotation into radial movement, both at constant speeds, according to the spiral of Archimedes. The loading unit equipped with eight jaws can hold the eye sample tightly. The developed device was validated with a spring of known constant and was further tested with anterior porcine eye segments. The validation experiment using the spring resulted in stiffness values close to the theoretical spring constant. Findings from measurements with porcine eye samples indicated that the measured forces are within the ranges reported in the literature. The developed multi-axis stretching device has good repeatability during experiments with similar settings and can be reliably used for mechanical evaluations of the intact eye lens.
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spelling pubmed-99525462023-02-25 Design of an Automatically Controlled Multi-Axis Stretching Device for Mechanical Evaluations of the Anterior Eye Segment Wang, Kehao Qiu, Ziyan Xie, Yiping Cai, Shuo Zhao, Yang Pierscionek, Barbara K. Guo, Jiangzhen Fan, Yubo Bioengineering (Basel) Article The young eye has an accommodative ability involving lens shape changes to focus over different distances. This function gradually decreases with age, resulting in presbyopia. Greater insights into the mechanical properties of anterior eye structures can improve understanding of the causes of presbyopia. The present study aims to develop a multi-axis stretching device for evaluating the mechanical properties of the intact eye lens. A stretching device integrating the mechanical stretcher, motor, torque sensor and data transmission mechanism was designed and developed by 3D printing. The mechanical stretcher can convert rotation into radial movement, both at constant speeds, according to the spiral of Archimedes. The loading unit equipped with eight jaws can hold the eye sample tightly. The developed device was validated with a spring of known constant and was further tested with anterior porcine eye segments. The validation experiment using the spring resulted in stiffness values close to the theoretical spring constant. Findings from measurements with porcine eye samples indicated that the measured forces are within the ranges reported in the literature. The developed multi-axis stretching device has good repeatability during experiments with similar settings and can be reliably used for mechanical evaluations of the intact eye lens. MDPI 2023-01-20 /pmc/articles/PMC9952546/ /pubmed/36829636 http://dx.doi.org/10.3390/bioengineering10020142 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Kehao
Qiu, Ziyan
Xie, Yiping
Cai, Shuo
Zhao, Yang
Pierscionek, Barbara K.
Guo, Jiangzhen
Fan, Yubo
Design of an Automatically Controlled Multi-Axis Stretching Device for Mechanical Evaluations of the Anterior Eye Segment
title Design of an Automatically Controlled Multi-Axis Stretching Device for Mechanical Evaluations of the Anterior Eye Segment
title_full Design of an Automatically Controlled Multi-Axis Stretching Device for Mechanical Evaluations of the Anterior Eye Segment
title_fullStr Design of an Automatically Controlled Multi-Axis Stretching Device for Mechanical Evaluations of the Anterior Eye Segment
title_full_unstemmed Design of an Automatically Controlled Multi-Axis Stretching Device for Mechanical Evaluations of the Anterior Eye Segment
title_short Design of an Automatically Controlled Multi-Axis Stretching Device for Mechanical Evaluations of the Anterior Eye Segment
title_sort design of an automatically controlled multi-axis stretching device for mechanical evaluations of the anterior eye segment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952546/
https://www.ncbi.nlm.nih.gov/pubmed/36829636
http://dx.doi.org/10.3390/bioengineering10020142
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