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Impact of Antibiotic Consumption on Antimicrobial Resistance to Invasive Hospital Pathogens

The aim of our investigation is to correlate the wholesale data on antibiotic consumption expressed in daily doses per 1000 inhabitants per day (DID) with the resistance rate of invasive pathogen bacteria from 2017 to 2021. The data on antimicrobial resistance were collected from an analysis of the...

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Autores principales: Medic, Deana, Bozic Cvijan, Bojana, Bajcetic, Milica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952588/
https://www.ncbi.nlm.nih.gov/pubmed/36830170
http://dx.doi.org/10.3390/antibiotics12020259
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author Medic, Deana
Bozic Cvijan, Bojana
Bajcetic, Milica
author_facet Medic, Deana
Bozic Cvijan, Bojana
Bajcetic, Milica
author_sort Medic, Deana
collection PubMed
description The aim of our investigation is to correlate the wholesale data on antibiotic consumption expressed in daily doses per 1000 inhabitants per day (DID) with the resistance rate of invasive pathogen bacteria from 2017 to 2021. The data on antimicrobial resistance were collected from an analysis of the primary isolates of hospitalized patients. According to the CAESAR manual, the selected pathogens isolated from blood culture and cerebrospinal fluids were tested. The consumption of antibiotics for systematic use showed a statistically significant increasing trend (β = 0.982, p = 0.003) from 21.3 DID in 2017 to 34.5 DID in 2021. The ratio of the utilization of broad-spectrum to narrow-spectrum antibiotics increased by 16% (β = 0.530, p = 0.358). The most consumed antibiotic in 2021 was azithromycin (15% of total consumption), followed by levofloxacin (13%) and cefixime (12%). A statistically positive significant correlation was discovered between the percentage of resistant isolates of K. pneumoniae and consumption of meropenem (r = 0.950; p = 0.013), ertapenem (r = 0.929; p = 0.022), ceftriaxone (r = 0.924; p = 0.025) and levofloxacin (r = 0.983; p = 0.003). Additionally, the percentage of resistant isolates of E. coli and consumption of ertapenem showed significant correlation (r = 0.955; p = 0.011). Significant correlation with consumption of the antibiotics widely used at the community level, such as levofloxacin, and resistance isolated in hospitals indicates that hospital stewardship is unlikely to be effective without a reduction in antibiotic misuse at the community level.
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spelling pubmed-99525882023-02-25 Impact of Antibiotic Consumption on Antimicrobial Resistance to Invasive Hospital Pathogens Medic, Deana Bozic Cvijan, Bojana Bajcetic, Milica Antibiotics (Basel) Article The aim of our investigation is to correlate the wholesale data on antibiotic consumption expressed in daily doses per 1000 inhabitants per day (DID) with the resistance rate of invasive pathogen bacteria from 2017 to 2021. The data on antimicrobial resistance were collected from an analysis of the primary isolates of hospitalized patients. According to the CAESAR manual, the selected pathogens isolated from blood culture and cerebrospinal fluids were tested. The consumption of antibiotics for systematic use showed a statistically significant increasing trend (β = 0.982, p = 0.003) from 21.3 DID in 2017 to 34.5 DID in 2021. The ratio of the utilization of broad-spectrum to narrow-spectrum antibiotics increased by 16% (β = 0.530, p = 0.358). The most consumed antibiotic in 2021 was azithromycin (15% of total consumption), followed by levofloxacin (13%) and cefixime (12%). A statistically positive significant correlation was discovered between the percentage of resistant isolates of K. pneumoniae and consumption of meropenem (r = 0.950; p = 0.013), ertapenem (r = 0.929; p = 0.022), ceftriaxone (r = 0.924; p = 0.025) and levofloxacin (r = 0.983; p = 0.003). Additionally, the percentage of resistant isolates of E. coli and consumption of ertapenem showed significant correlation (r = 0.955; p = 0.011). Significant correlation with consumption of the antibiotics widely used at the community level, such as levofloxacin, and resistance isolated in hospitals indicates that hospital stewardship is unlikely to be effective without a reduction in antibiotic misuse at the community level. MDPI 2023-01-28 /pmc/articles/PMC9952588/ /pubmed/36830170 http://dx.doi.org/10.3390/antibiotics12020259 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Medic, Deana
Bozic Cvijan, Bojana
Bajcetic, Milica
Impact of Antibiotic Consumption on Antimicrobial Resistance to Invasive Hospital Pathogens
title Impact of Antibiotic Consumption on Antimicrobial Resistance to Invasive Hospital Pathogens
title_full Impact of Antibiotic Consumption on Antimicrobial Resistance to Invasive Hospital Pathogens
title_fullStr Impact of Antibiotic Consumption on Antimicrobial Resistance to Invasive Hospital Pathogens
title_full_unstemmed Impact of Antibiotic Consumption on Antimicrobial Resistance to Invasive Hospital Pathogens
title_short Impact of Antibiotic Consumption on Antimicrobial Resistance to Invasive Hospital Pathogens
title_sort impact of antibiotic consumption on antimicrobial resistance to invasive hospital pathogens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952588/
https://www.ncbi.nlm.nih.gov/pubmed/36830170
http://dx.doi.org/10.3390/antibiotics12020259
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