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Clinical Experiences and Mechanism of Action with the Use of Oxytocin Injection at Parturition in Domestic Animals: Effect on the Myometrium and Fetuses

SIMPLE SUMMARY: Oxytocin is a hormone that plays an important role in parturition. For this reason, in animal production farms, the exogenous application of this substance is regularly used to help in reducing calving times. However, this hormone can indirectly reduce vitality in the newborn by a di...

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Autores principales: Marcet-Rius, Míriam, Bienboire-Frosini, Cécile, Lezama-García, Karina, Domínguez-Oliva, Adriana, Olmos-Hernández, Adriana, Mora-Medina, Patricia, Hernández-Ávalos, Ismael, Casas-Alvarado, Alejandro, Gazzano, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952595/
https://www.ncbi.nlm.nih.gov/pubmed/36830555
http://dx.doi.org/10.3390/ani13040768
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author Marcet-Rius, Míriam
Bienboire-Frosini, Cécile
Lezama-García, Karina
Domínguez-Oliva, Adriana
Olmos-Hernández, Adriana
Mora-Medina, Patricia
Hernández-Ávalos, Ismael
Casas-Alvarado, Alejandro
Gazzano, Angelo
author_facet Marcet-Rius, Míriam
Bienboire-Frosini, Cécile
Lezama-García, Karina
Domínguez-Oliva, Adriana
Olmos-Hernández, Adriana
Mora-Medina, Patricia
Hernández-Ávalos, Ismael
Casas-Alvarado, Alejandro
Gazzano, Angelo
author_sort Marcet-Rius, Míriam
collection PubMed
description SIMPLE SUMMARY: Oxytocin is a hormone that plays an important role in parturition. For this reason, in animal production farms, the exogenous application of this substance is regularly used to help in reducing calving times. However, this hormone can indirectly reduce vitality in the newborn by a direct effect on the intensity of uterine contractions, inducing fetal hypoxia and affecting neonate mortality and thereby a significant economic loss when it is administered in high doses or at times when it is not required. For this reason, the aim is to review the proper administration of oxytocin in domestic animals. ABSTRACT: Oxytocin is a key hormone for parturition and maternal traits in animals. During the peripartum period, the levels of endogenous oxytocin dictate physiological events such as myometrial contractions, prostaglandin production with the subsequent increase in oxytocin receptors, and the promotion of lactation when administered immediately after birth. While this hormone has some benefits regarding these aspects, the exogenous administration of oxytocin has been shown to have detrimental effects on the fetus, such as asphyxia, meconium staining, ruptured umbilical cords, and more dystocia cases in females. This review aims to analyze the main effects of oxytocin on myometrial activity during parturition, and its potential favorable and negative administration effects reflected in the fetus health of domestic animals. In conclusion, it is convenient to know oxytocin’s different effects as well as the adequate doses and the proper moment to administrate it, as it can reduce labor duration, but it can also increase dystocia.
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spelling pubmed-99525952023-02-25 Clinical Experiences and Mechanism of Action with the Use of Oxytocin Injection at Parturition in Domestic Animals: Effect on the Myometrium and Fetuses Marcet-Rius, Míriam Bienboire-Frosini, Cécile Lezama-García, Karina Domínguez-Oliva, Adriana Olmos-Hernández, Adriana Mora-Medina, Patricia Hernández-Ávalos, Ismael Casas-Alvarado, Alejandro Gazzano, Angelo Animals (Basel) Review SIMPLE SUMMARY: Oxytocin is a hormone that plays an important role in parturition. For this reason, in animal production farms, the exogenous application of this substance is regularly used to help in reducing calving times. However, this hormone can indirectly reduce vitality in the newborn by a direct effect on the intensity of uterine contractions, inducing fetal hypoxia and affecting neonate mortality and thereby a significant economic loss when it is administered in high doses or at times when it is not required. For this reason, the aim is to review the proper administration of oxytocin in domestic animals. ABSTRACT: Oxytocin is a key hormone for parturition and maternal traits in animals. During the peripartum period, the levels of endogenous oxytocin dictate physiological events such as myometrial contractions, prostaglandin production with the subsequent increase in oxytocin receptors, and the promotion of lactation when administered immediately after birth. While this hormone has some benefits regarding these aspects, the exogenous administration of oxytocin has been shown to have detrimental effects on the fetus, such as asphyxia, meconium staining, ruptured umbilical cords, and more dystocia cases in females. This review aims to analyze the main effects of oxytocin on myometrial activity during parturition, and its potential favorable and negative administration effects reflected in the fetus health of domestic animals. In conclusion, it is convenient to know oxytocin’s different effects as well as the adequate doses and the proper moment to administrate it, as it can reduce labor duration, but it can also increase dystocia. MDPI 2023-02-20 /pmc/articles/PMC9952595/ /pubmed/36830555 http://dx.doi.org/10.3390/ani13040768 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Marcet-Rius, Míriam
Bienboire-Frosini, Cécile
Lezama-García, Karina
Domínguez-Oliva, Adriana
Olmos-Hernández, Adriana
Mora-Medina, Patricia
Hernández-Ávalos, Ismael
Casas-Alvarado, Alejandro
Gazzano, Angelo
Clinical Experiences and Mechanism of Action with the Use of Oxytocin Injection at Parturition in Domestic Animals: Effect on the Myometrium and Fetuses
title Clinical Experiences and Mechanism of Action with the Use of Oxytocin Injection at Parturition in Domestic Animals: Effect on the Myometrium and Fetuses
title_full Clinical Experiences and Mechanism of Action with the Use of Oxytocin Injection at Parturition in Domestic Animals: Effect on the Myometrium and Fetuses
title_fullStr Clinical Experiences and Mechanism of Action with the Use of Oxytocin Injection at Parturition in Domestic Animals: Effect on the Myometrium and Fetuses
title_full_unstemmed Clinical Experiences and Mechanism of Action with the Use of Oxytocin Injection at Parturition in Domestic Animals: Effect on the Myometrium and Fetuses
title_short Clinical Experiences and Mechanism of Action with the Use of Oxytocin Injection at Parturition in Domestic Animals: Effect on the Myometrium and Fetuses
title_sort clinical experiences and mechanism of action with the use of oxytocin injection at parturition in domestic animals: effect on the myometrium and fetuses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952595/
https://www.ncbi.nlm.nih.gov/pubmed/36830555
http://dx.doi.org/10.3390/ani13040768
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