Di-(2-ethylhexyl) Phthalate Limits the Lipid-Lowering Effects of Simvastatin by Promoting Protein Degradation of Low-Density Lipoprotein Receptor: Role of PPARγ-PCSK9 and LXRα-IDOL Signaling Pathways

Dialysis prevents death from uremia in patients with end-stage renal disease (ESRD). Nevertheless, during hemodialysis, circulating levels of di-(2-ethylhexyl) phthalate (DEHP) are increased due to phthalates leaching from medical tubes. Statins are an effective therapy for reducing the risks associ...

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Detalles Bibliográficos
Autores principales: Guo, Bei-Chia, Kuo, Ko-Lin, Huang, Jenq-Wen, Chen, Chia-Hui, Tarng, Der-Cherng, Lee, Tzong-Shyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952605/
https://www.ncbi.nlm.nih.gov/pubmed/36830035
http://dx.doi.org/10.3390/antiox12020477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952605/
https://www.ncbi.nlm.nih.gov/pubmed/36830035
http://dx.doi.org/10.3390/antiox12020477

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