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Current and Future Pathways in Aspergillus Diagnosis
Aspergillus fumigatus has been designated by the World Health Organization as a critical priority fungal pathogen. Some commercially available diagnostics for many forms of aspergillosis rely on fungal metabolites. These encompass intracellular molecules, cell wall components, and extracellular secr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952630/ https://www.ncbi.nlm.nih.gov/pubmed/36830296 http://dx.doi.org/10.3390/antibiotics12020385 |
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author | Dobiáš, Radim Stevens, David A. Havlíček, Vladimír |
author_facet | Dobiáš, Radim Stevens, David A. Havlíček, Vladimír |
author_sort | Dobiáš, Radim |
collection | PubMed |
description | Aspergillus fumigatus has been designated by the World Health Organization as a critical priority fungal pathogen. Some commercially available diagnostics for many forms of aspergillosis rely on fungal metabolites. These encompass intracellular molecules, cell wall components, and extracellular secretomes. This review summarizes the shortcomings of antibody tests compared to tests of fungal products in body fluids and highlights the application of β-d-glucan, galactomannan, and pentraxin 3 in bronchoalveolar lavage fluids. We also discuss the detection of nucleic acids and next-generation sequencing, along with newer studies on Aspergillus metallophores. |
format | Online Article Text |
id | pubmed-9952630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99526302023-02-25 Current and Future Pathways in Aspergillus Diagnosis Dobiáš, Radim Stevens, David A. Havlíček, Vladimír Antibiotics (Basel) Review Aspergillus fumigatus has been designated by the World Health Organization as a critical priority fungal pathogen. Some commercially available diagnostics for many forms of aspergillosis rely on fungal metabolites. These encompass intracellular molecules, cell wall components, and extracellular secretomes. This review summarizes the shortcomings of antibody tests compared to tests of fungal products in body fluids and highlights the application of β-d-glucan, galactomannan, and pentraxin 3 in bronchoalveolar lavage fluids. We also discuss the detection of nucleic acids and next-generation sequencing, along with newer studies on Aspergillus metallophores. MDPI 2023-02-13 /pmc/articles/PMC9952630/ /pubmed/36830296 http://dx.doi.org/10.3390/antibiotics12020385 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dobiáš, Radim Stevens, David A. Havlíček, Vladimír Current and Future Pathways in Aspergillus Diagnosis |
title | Current and Future Pathways in Aspergillus Diagnosis |
title_full | Current and Future Pathways in Aspergillus Diagnosis |
title_fullStr | Current and Future Pathways in Aspergillus Diagnosis |
title_full_unstemmed | Current and Future Pathways in Aspergillus Diagnosis |
title_short | Current and Future Pathways in Aspergillus Diagnosis |
title_sort | current and future pathways in aspergillus diagnosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952630/ https://www.ncbi.nlm.nih.gov/pubmed/36830296 http://dx.doi.org/10.3390/antibiotics12020385 |
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