Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment

Amnestic mild cognitive impairment (MCI), arguably the earliest clinical stage of Alzheimer disease (AD), is characterized by normal activities of daily living but with memory issues but no dementia. Oxidative stress, with consequent damaged key proteins and lipids, are prominent even in this early...

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Detalles Bibliográficos
Autor principal: Butterfield, D. Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952700/
https://www.ncbi.nlm.nih.gov/pubmed/36830020
http://dx.doi.org/10.3390/antiox12020462
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author Butterfield, D. Allan
author_facet Butterfield, D. Allan
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description Amnestic mild cognitive impairment (MCI), arguably the earliest clinical stage of Alzheimer disease (AD), is characterized by normal activities of daily living but with memory issues but no dementia. Oxidative stress, with consequent damaged key proteins and lipids, are prominent even in this early state of AD. This review article outlines oxidative stress in MCI and how this can account for neuronal loss and potential therapeutic strategies to slow progression to AD.
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spelling pubmed-99527002023-02-25 Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment Butterfield, D. Allan Antioxidants (Basel) Review Amnestic mild cognitive impairment (MCI), arguably the earliest clinical stage of Alzheimer disease (AD), is characterized by normal activities of daily living but with memory issues but no dementia. Oxidative stress, with consequent damaged key proteins and lipids, are prominent even in this early state of AD. This review article outlines oxidative stress in MCI and how this can account for neuronal loss and potential therapeutic strategies to slow progression to AD. MDPI 2023-02-11 /pmc/articles/PMC9952700/ /pubmed/36830020 http://dx.doi.org/10.3390/antiox12020462 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Butterfield, D. Allan
Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment
title Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment
title_full Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment
title_fullStr Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment
title_full_unstemmed Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment
title_short Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment
title_sort oxidative stress in brain in amnestic mild cognitive impairment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952700/
https://www.ncbi.nlm.nih.gov/pubmed/36830020
http://dx.doi.org/10.3390/antiox12020462
work_keys_str_mv AT butterfielddallan oxidativestressinbraininamnesticmildcognitiveimpairment

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