Rare Variants in LRP4 Are Associated with Mesiodens, Root Maldevelopment, and Oral Exostoses in Humans

SIMPLE SUMMARY: Low density lipoprotein receptor-related protein 4 (LRP4; MIM 604270) modulates WNT/β-catenin signaling, through its binding of WNT ligands, and to co-receptors LRP5/6, and WNT inhibitors DKK1, SOSTDC1, and SOST. LRP4 binds to SOSTDC1 and WNT proteins establishing a negative feedback...

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Detalles Bibliográficos
Autores principales: Kantaputra, Piranit Nik, Jatooratthawichot, Peeranat, Adisornkanj, Ploy, Kitsadayurach, Panita, Kaewgahya, Massupa, Olsen, Bjorn, Ohazama, Atsushi, Ngamphiw, Chumpol, Tongsima, Sissades, Cox, Timothy C., Ketudat Cairns, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952772/
https://www.ncbi.nlm.nih.gov/pubmed/36829498
http://dx.doi.org/10.3390/biology12020220

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