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Natural Medicine a Promising Candidate in Combating Microbial Biofilm

Studies on biofilm-related infections are gaining prominence owing to their involvement in most clinical infections and seriously threatening global public health. A biofilm is a natural form of bacterial growth ubiquitous in ecological niches, considered to be a generic survival mechanism adopted b...

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Autores principales: Shamim, Athar, Ali, Asgar, Iqbal, Zeenat, Mirza, Mohd Aamir, Aqil, Mohd, Kawish, S. M., Siddiqui, Ayesha, Kumar, Vijay, Naseef, Punnoth Poonkuzhi, Alshadidi, Abdulkhaliq Ali F., Saheer Kuruniyan, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952808/
https://www.ncbi.nlm.nih.gov/pubmed/36830210
http://dx.doi.org/10.3390/antibiotics12020299
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author Shamim, Athar
Ali, Asgar
Iqbal, Zeenat
Mirza, Mohd Aamir
Aqil, Mohd
Kawish, S. M.
Siddiqui, Ayesha
Kumar, Vijay
Naseef, Punnoth Poonkuzhi
Alshadidi, Abdulkhaliq Ali F.
Saheer Kuruniyan, Mohamed
author_facet Shamim, Athar
Ali, Asgar
Iqbal, Zeenat
Mirza, Mohd Aamir
Aqil, Mohd
Kawish, S. M.
Siddiqui, Ayesha
Kumar, Vijay
Naseef, Punnoth Poonkuzhi
Alshadidi, Abdulkhaliq Ali F.
Saheer Kuruniyan, Mohamed
author_sort Shamim, Athar
collection PubMed
description Studies on biofilm-related infections are gaining prominence owing to their involvement in most clinical infections and seriously threatening global public health. A biofilm is a natural form of bacterial growth ubiquitous in ecological niches, considered to be a generic survival mechanism adopted by both pathogenic and non-pathogenic microorganisms and entailing heterogeneous cell development within the matrix. In the ecological niche, quorum sensing is a communication channel that is crucial to developing biofilms. Biofilm formation leads to increased resistance to unfavourable ecological effects, comprising resistance to antibiotics and antimicrobial agents. Biofilms are frequently combated with modern conventional medicines such as antibiotics, but at present, they are considered inadequate for the treatment of multi-drug resistance; therefore, it is vital to discover some new antimicrobial agents that can prevent the production and growth of biofilm, in addition to minimizing the side effects of such therapies. In the search for some alternative and safe therapies, natural plant-derived phytomedicines are gaining popularity among the research community. Phytomedicines are natural agents derived from natural plants. These plant-derived agents may include flavonoids, terpenoids, lectins, alkaloids, polypeptides, polyacetylenes, phenolics, and essential oils. Since they are natural agents, they cause minimal side effects, so could be administered with dose flexibility. It is vital to discover some new antimicrobial agents that can control the production and growth of biofilms. This review summarizes and analyzes the efficacy characteristics and corresponding mechanisms of natural-product-based antibiofilm agents, i.e., phytochemicals, biosurfactants, antimicrobial peptides, and their sources, along with their mechanism, quorum sensing signalling pathways, disrupting extracellular matrix adhesion. The review also provides some other strategies to inhibit biofilm-related illness. The prepared list of newly discovered natural antibiofilm agents could help in devising novel strategies for biofilm-associated infections.
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spelling pubmed-99528082023-02-25 Natural Medicine a Promising Candidate in Combating Microbial Biofilm Shamim, Athar Ali, Asgar Iqbal, Zeenat Mirza, Mohd Aamir Aqil, Mohd Kawish, S. M. Siddiqui, Ayesha Kumar, Vijay Naseef, Punnoth Poonkuzhi Alshadidi, Abdulkhaliq Ali F. Saheer Kuruniyan, Mohamed Antibiotics (Basel) Review Studies on biofilm-related infections are gaining prominence owing to their involvement in most clinical infections and seriously threatening global public health. A biofilm is a natural form of bacterial growth ubiquitous in ecological niches, considered to be a generic survival mechanism adopted by both pathogenic and non-pathogenic microorganisms and entailing heterogeneous cell development within the matrix. In the ecological niche, quorum sensing is a communication channel that is crucial to developing biofilms. Biofilm formation leads to increased resistance to unfavourable ecological effects, comprising resistance to antibiotics and antimicrobial agents. Biofilms are frequently combated with modern conventional medicines such as antibiotics, but at present, they are considered inadequate for the treatment of multi-drug resistance; therefore, it is vital to discover some new antimicrobial agents that can prevent the production and growth of biofilm, in addition to minimizing the side effects of such therapies. In the search for some alternative and safe therapies, natural plant-derived phytomedicines are gaining popularity among the research community. Phytomedicines are natural agents derived from natural plants. These plant-derived agents may include flavonoids, terpenoids, lectins, alkaloids, polypeptides, polyacetylenes, phenolics, and essential oils. Since they are natural agents, they cause minimal side effects, so could be administered with dose flexibility. It is vital to discover some new antimicrobial agents that can control the production and growth of biofilms. This review summarizes and analyzes the efficacy characteristics and corresponding mechanisms of natural-product-based antibiofilm agents, i.e., phytochemicals, biosurfactants, antimicrobial peptides, and their sources, along with their mechanism, quorum sensing signalling pathways, disrupting extracellular matrix adhesion. The review also provides some other strategies to inhibit biofilm-related illness. The prepared list of newly discovered natural antibiofilm agents could help in devising novel strategies for biofilm-associated infections. MDPI 2023-02-02 /pmc/articles/PMC9952808/ /pubmed/36830210 http://dx.doi.org/10.3390/antibiotics12020299 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shamim, Athar
Ali, Asgar
Iqbal, Zeenat
Mirza, Mohd Aamir
Aqil, Mohd
Kawish, S. M.
Siddiqui, Ayesha
Kumar, Vijay
Naseef, Punnoth Poonkuzhi
Alshadidi, Abdulkhaliq Ali F.
Saheer Kuruniyan, Mohamed
Natural Medicine a Promising Candidate in Combating Microbial Biofilm
title Natural Medicine a Promising Candidate in Combating Microbial Biofilm
title_full Natural Medicine a Promising Candidate in Combating Microbial Biofilm
title_fullStr Natural Medicine a Promising Candidate in Combating Microbial Biofilm
title_full_unstemmed Natural Medicine a Promising Candidate in Combating Microbial Biofilm
title_short Natural Medicine a Promising Candidate in Combating Microbial Biofilm
title_sort natural medicine a promising candidate in combating microbial biofilm
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952808/
https://www.ncbi.nlm.nih.gov/pubmed/36830210
http://dx.doi.org/10.3390/antibiotics12020299
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