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Correlates of Taxane-Induced Neuropathy, an Electronic Health Record Based Observational Study
SIMPLE SUMMARY: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of taxane chemotherapy. We investigated the associations of demographic and treatment variables with the risk of developing CIPN using electronic health record data. We found higher doses, more taxane cycles...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952888/ https://www.ncbi.nlm.nih.gov/pubmed/36765713 http://dx.doi.org/10.3390/cancers15030754 |
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author | Dorand, R. Dixon Zheng, Neil S. Agarwal, Rajiv Carroll, Robert J. Rubinstein, Samuel M. Winkfield, Karen M. Wei, Wei-Qi Berlin, Jordan Shu, Xiao-Ou |
author_facet | Dorand, R. Dixon Zheng, Neil S. Agarwal, Rajiv Carroll, Robert J. Rubinstein, Samuel M. Winkfield, Karen M. Wei, Wei-Qi Berlin, Jordan Shu, Xiao-Ou |
author_sort | Dorand, R. Dixon |
collection | PubMed |
description | SIMPLE SUMMARY: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of taxane chemotherapy. We investigated the associations of demographic and treatment variables with the risk of developing CIPN using electronic health record data. We found higher doses, more taxane cycles, female sex, overweight and obesity, or a history of diabetes were associated with developing CIPN in patients treated with taxane, while concurrent chemotherapy or concurrent radiotherapy were related to a reduced risk. Further studies are needed to uncover the underlying reasons for the observed associations. ABSTRACT: Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common therapeutic complication affecting cancer patients’ quality-of-life. We evaluated clinical characteristics, demographics, and lifestyle factors in association with CIPN following taxane treatment. Methods: Data were extracted from the electronic health record of 3387 patients diagnosed with a primary cancer and receiving taxane (i.e., paclitaxel or docetaxel) at Vanderbilt University Medical Center. Neuropathy was assessed via a validated computer algorithm. Univariate and multivariate regression models were applied to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) of CIPN-associated factors. Results: Female sex (OR = 1.28, 95% CI = 1.01–1.62), high body-mass index (BMI) (OR = 1.31, 95% CI = 1.06–1.61 for overweight, and OR = 1.49, 95% CI = 1.21–1.83 for obesity), diabetes (OR = 1.66, 95% CI = 1.34–2.06), high mean taxane dose (OR = 1.05, 95% CI = 1.03–1.08 per 10 mg/m(2)), and more treatment cycles (1.12, 95% CI = 1.10–1.14) were positively associated with CIPN. Concurrent chemotherapy (OR = 0.74, 95% CI = 0.58–0.94) and concurrent radiotherapy (OR = 0.77, 95% CI = 0.59–1.00) were inversely associated with CIPN. Obesity and diabetes both had a stronger association with docetaxel CIPN compared to paclitaxel, although interaction was only significant for diabetes and taxane (p = 0.019). Increased BMI was associated with CIPN only among non-diabetic patients (OR:1.34 for overweight and 1.68 for obesity), while diabetes increased CIPN risk across all BMI strata (ORs were 2.65, 2.41, and 2.15 for normal weight, overweight, and obese, respectively) compared to normal-weight non-diabetic patients (p for interaction = 0.039). Conclusions: Female sex, obesity, and diabetes are significantly associated with taxine-induced CIPN. Further research is needed to identify clinical and pharmacologic strategies to prevent and mitigate CIPN in at-risk patient populations. |
format | Online Article Text |
id | pubmed-9952888 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99528882023-02-25 Correlates of Taxane-Induced Neuropathy, an Electronic Health Record Based Observational Study Dorand, R. Dixon Zheng, Neil S. Agarwal, Rajiv Carroll, Robert J. Rubinstein, Samuel M. Winkfield, Karen M. Wei, Wei-Qi Berlin, Jordan Shu, Xiao-Ou Cancers (Basel) Article SIMPLE SUMMARY: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of taxane chemotherapy. We investigated the associations of demographic and treatment variables with the risk of developing CIPN using electronic health record data. We found higher doses, more taxane cycles, female sex, overweight and obesity, or a history of diabetes were associated with developing CIPN in patients treated with taxane, while concurrent chemotherapy or concurrent radiotherapy were related to a reduced risk. Further studies are needed to uncover the underlying reasons for the observed associations. ABSTRACT: Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common therapeutic complication affecting cancer patients’ quality-of-life. We evaluated clinical characteristics, demographics, and lifestyle factors in association with CIPN following taxane treatment. Methods: Data were extracted from the electronic health record of 3387 patients diagnosed with a primary cancer and receiving taxane (i.e., paclitaxel or docetaxel) at Vanderbilt University Medical Center. Neuropathy was assessed via a validated computer algorithm. Univariate and multivariate regression models were applied to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) of CIPN-associated factors. Results: Female sex (OR = 1.28, 95% CI = 1.01–1.62), high body-mass index (BMI) (OR = 1.31, 95% CI = 1.06–1.61 for overweight, and OR = 1.49, 95% CI = 1.21–1.83 for obesity), diabetes (OR = 1.66, 95% CI = 1.34–2.06), high mean taxane dose (OR = 1.05, 95% CI = 1.03–1.08 per 10 mg/m(2)), and more treatment cycles (1.12, 95% CI = 1.10–1.14) were positively associated with CIPN. Concurrent chemotherapy (OR = 0.74, 95% CI = 0.58–0.94) and concurrent radiotherapy (OR = 0.77, 95% CI = 0.59–1.00) were inversely associated with CIPN. Obesity and diabetes both had a stronger association with docetaxel CIPN compared to paclitaxel, although interaction was only significant for diabetes and taxane (p = 0.019). Increased BMI was associated with CIPN only among non-diabetic patients (OR:1.34 for overweight and 1.68 for obesity), while diabetes increased CIPN risk across all BMI strata (ORs were 2.65, 2.41, and 2.15 for normal weight, overweight, and obese, respectively) compared to normal-weight non-diabetic patients (p for interaction = 0.039). Conclusions: Female sex, obesity, and diabetes are significantly associated with taxine-induced CIPN. Further research is needed to identify clinical and pharmacologic strategies to prevent and mitigate CIPN in at-risk patient populations. MDPI 2023-01-26 /pmc/articles/PMC9952888/ /pubmed/36765713 http://dx.doi.org/10.3390/cancers15030754 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dorand, R. Dixon Zheng, Neil S. Agarwal, Rajiv Carroll, Robert J. Rubinstein, Samuel M. Winkfield, Karen M. Wei, Wei-Qi Berlin, Jordan Shu, Xiao-Ou Correlates of Taxane-Induced Neuropathy, an Electronic Health Record Based Observational Study |
title | Correlates of Taxane-Induced Neuropathy, an Electronic Health Record Based Observational Study |
title_full | Correlates of Taxane-Induced Neuropathy, an Electronic Health Record Based Observational Study |
title_fullStr | Correlates of Taxane-Induced Neuropathy, an Electronic Health Record Based Observational Study |
title_full_unstemmed | Correlates of Taxane-Induced Neuropathy, an Electronic Health Record Based Observational Study |
title_short | Correlates of Taxane-Induced Neuropathy, an Electronic Health Record Based Observational Study |
title_sort | correlates of taxane-induced neuropathy, an electronic health record based observational study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952888/ https://www.ncbi.nlm.nih.gov/pubmed/36765713 http://dx.doi.org/10.3390/cancers15030754 |
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