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Quantitative Autofluorescence in Non-Neovascular Age Related Macular Degeneration

Quantitative autofluorescence (qAF8) level is a presumed surrogate marker of lipofuscin content in the retina. We investigated the changes in the qAF8 levels in non-neovascular AMD. In this prospective cohort study, Caucasians aged ≥50 years with varying severity of non-neovascular AMD in at least o...

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Autores principales: Chandra, Shruti, Grewal, Manjot K., Gurudas, Sarega, Sondh, Rajan, Bird, Alan, Jeffery, Glen, Chong, Victor, Sivaprasad, Sobha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952913/
https://www.ncbi.nlm.nih.gov/pubmed/36831096
http://dx.doi.org/10.3390/biomedicines11020560
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author Chandra, Shruti
Grewal, Manjot K.
Gurudas, Sarega
Sondh, Rajan
Bird, Alan
Jeffery, Glen
Chong, Victor
Sivaprasad, Sobha
author_facet Chandra, Shruti
Grewal, Manjot K.
Gurudas, Sarega
Sondh, Rajan
Bird, Alan
Jeffery, Glen
Chong, Victor
Sivaprasad, Sobha
author_sort Chandra, Shruti
collection PubMed
description Quantitative autofluorescence (qAF8) level is a presumed surrogate marker of lipofuscin content in the retina. We investigated the changes in the qAF8 levels in non-neovascular AMD. In this prospective cohort study, Caucasians aged ≥50 years with varying severity of non-neovascular AMD in at least one eye and Snellen visual acuity ≥6/18 were recruited. The qAF8 levels were analysed in the middle eight segments of the Delori pattern (HEYEX software, Heidelberg, Germany). The AMD categories were graded using both the Beckman classification and multimodal imaging (MMI) to include the presence of subretinal drusenoid deposits (SDD). A total of 353 eyes from 231 participants were analyzed. Compared with the age-matched controls, the qAF8 values decreased in the eyes with AMD (adjusted % difference = −19.7% [95% CI −28.8%, −10.4%]; p < 0.001) and across the AMD categories, (adjusted % differences; Early, −13.1% (−24.4%, −1%), p = 0.04; intermediate AMD (iAMD), −22.9% (−32.3%, −13.1%), p < 0.001; geographic atrophy −25.2% (−38.1%, −10.4%), p = 0.002). On MMI, the qAF8 was reduced in the AMD subgroups relative to the controls, (adjusted % differences; Early, −5.8% (−18.9%, 8.3%); p = 0.40; iAMD, −26.7% (−36.2%, −15.6%); p < 0.001; SDD, −23.7% (−33.6%, −12.2%); p < 0.001; atrophy, −26.7% (−39.3%, −11.3%), p = 0.001). The qAF8 levels declined early in AMD and were not significantly different between the severity levels of non-neovascular AMD, suggesting the early and sustained loss of function of the retinal pigment epithelium in AMD.
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spelling pubmed-99529132023-02-25 Quantitative Autofluorescence in Non-Neovascular Age Related Macular Degeneration Chandra, Shruti Grewal, Manjot K. Gurudas, Sarega Sondh, Rajan Bird, Alan Jeffery, Glen Chong, Victor Sivaprasad, Sobha Biomedicines Article Quantitative autofluorescence (qAF8) level is a presumed surrogate marker of lipofuscin content in the retina. We investigated the changes in the qAF8 levels in non-neovascular AMD. In this prospective cohort study, Caucasians aged ≥50 years with varying severity of non-neovascular AMD in at least one eye and Snellen visual acuity ≥6/18 were recruited. The qAF8 levels were analysed in the middle eight segments of the Delori pattern (HEYEX software, Heidelberg, Germany). The AMD categories were graded using both the Beckman classification and multimodal imaging (MMI) to include the presence of subretinal drusenoid deposits (SDD). A total of 353 eyes from 231 participants were analyzed. Compared with the age-matched controls, the qAF8 values decreased in the eyes with AMD (adjusted % difference = −19.7% [95% CI −28.8%, −10.4%]; p < 0.001) and across the AMD categories, (adjusted % differences; Early, −13.1% (−24.4%, −1%), p = 0.04; intermediate AMD (iAMD), −22.9% (−32.3%, −13.1%), p < 0.001; geographic atrophy −25.2% (−38.1%, −10.4%), p = 0.002). On MMI, the qAF8 was reduced in the AMD subgroups relative to the controls, (adjusted % differences; Early, −5.8% (−18.9%, 8.3%); p = 0.40; iAMD, −26.7% (−36.2%, −15.6%); p < 0.001; SDD, −23.7% (−33.6%, −12.2%); p < 0.001; atrophy, −26.7% (−39.3%, −11.3%), p = 0.001). The qAF8 levels declined early in AMD and were not significantly different between the severity levels of non-neovascular AMD, suggesting the early and sustained loss of function of the retinal pigment epithelium in AMD. MDPI 2023-02-15 /pmc/articles/PMC9952913/ /pubmed/36831096 http://dx.doi.org/10.3390/biomedicines11020560 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chandra, Shruti
Grewal, Manjot K.
Gurudas, Sarega
Sondh, Rajan
Bird, Alan
Jeffery, Glen
Chong, Victor
Sivaprasad, Sobha
Quantitative Autofluorescence in Non-Neovascular Age Related Macular Degeneration
title Quantitative Autofluorescence in Non-Neovascular Age Related Macular Degeneration
title_full Quantitative Autofluorescence in Non-Neovascular Age Related Macular Degeneration
title_fullStr Quantitative Autofluorescence in Non-Neovascular Age Related Macular Degeneration
title_full_unstemmed Quantitative Autofluorescence in Non-Neovascular Age Related Macular Degeneration
title_short Quantitative Autofluorescence in Non-Neovascular Age Related Macular Degeneration
title_sort quantitative autofluorescence in non-neovascular age related macular degeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952913/
https://www.ncbi.nlm.nih.gov/pubmed/36831096
http://dx.doi.org/10.3390/biomedicines11020560
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