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Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research
The retinal pigment epithelium (RPE) forms an important cellular monolayer, which contributes to the normal physiology of the eye. Damage to the RPE leads to the development of degenerative diseases, such as age-related macular degeneration (AMD). Apart from acting as a physical barrier between the...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952929/ https://www.ncbi.nlm.nih.gov/pubmed/36830851 http://dx.doi.org/10.3390/biomedicines11020310 |
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author | Gupta, Santosh Lytvynchuk, Lyubomyr Ardan, Taras Studenovska, Hana Faura, Georgina Eide, Lars Znaor, Ljubo Erceg, Slaven Stieger, Knut Motlik, Jan Bharti, Kapil Petrovski, Goran |
author_facet | Gupta, Santosh Lytvynchuk, Lyubomyr Ardan, Taras Studenovska, Hana Faura, Georgina Eide, Lars Znaor, Ljubo Erceg, Slaven Stieger, Knut Motlik, Jan Bharti, Kapil Petrovski, Goran |
author_sort | Gupta, Santosh |
collection | PubMed |
description | The retinal pigment epithelium (RPE) forms an important cellular monolayer, which contributes to the normal physiology of the eye. Damage to the RPE leads to the development of degenerative diseases, such as age-related macular degeneration (AMD). Apart from acting as a physical barrier between the retina and choroidal blood vessels, the RPE is crucial in maintaining photoreceptor (PR) and visual functions. Current clinical intervention to treat early stages of AMD includes stem cell-derived RPE transplantation, which is still in its early stages of evolution. Therefore, it becomes essential to derive RPEs which are functional and exhibit features as observed in native human RPE cells. The conventional strategy is to use the knowledge obtained from developmental studies using various animal models and stem cell-based exploratory studies to understand RPE biogenies and developmental trajectory. This article emphasises such studies and aims to present a comprehensive understanding of the basic biology, including the genetics and molecular pathways of RPE development. It encompasses basic developmental biology and stem cell-based developmental studies to uncover RPE differentiation. Knowledge of the in utero developmental cues provides an inclusive methodology required for deriving RPEs using stem cells. |
format | Online Article Text |
id | pubmed-9952929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99529292023-02-25 Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research Gupta, Santosh Lytvynchuk, Lyubomyr Ardan, Taras Studenovska, Hana Faura, Georgina Eide, Lars Znaor, Ljubo Erceg, Slaven Stieger, Knut Motlik, Jan Bharti, Kapil Petrovski, Goran Biomedicines Review The retinal pigment epithelium (RPE) forms an important cellular monolayer, which contributes to the normal physiology of the eye. Damage to the RPE leads to the development of degenerative diseases, such as age-related macular degeneration (AMD). Apart from acting as a physical barrier between the retina and choroidal blood vessels, the RPE is crucial in maintaining photoreceptor (PR) and visual functions. Current clinical intervention to treat early stages of AMD includes stem cell-derived RPE transplantation, which is still in its early stages of evolution. Therefore, it becomes essential to derive RPEs which are functional and exhibit features as observed in native human RPE cells. The conventional strategy is to use the knowledge obtained from developmental studies using various animal models and stem cell-based exploratory studies to understand RPE biogenies and developmental trajectory. This article emphasises such studies and aims to present a comprehensive understanding of the basic biology, including the genetics and molecular pathways of RPE development. It encompasses basic developmental biology and stem cell-based developmental studies to uncover RPE differentiation. Knowledge of the in utero developmental cues provides an inclusive methodology required for deriving RPEs using stem cells. MDPI 2023-01-23 /pmc/articles/PMC9952929/ /pubmed/36830851 http://dx.doi.org/10.3390/biomedicines11020310 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gupta, Santosh Lytvynchuk, Lyubomyr Ardan, Taras Studenovska, Hana Faura, Georgina Eide, Lars Znaor, Ljubo Erceg, Slaven Stieger, Knut Motlik, Jan Bharti, Kapil Petrovski, Goran Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research |
title | Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research |
title_full | Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research |
title_fullStr | Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research |
title_full_unstemmed | Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research |
title_short | Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research |
title_sort | retinal pigment epithelium cell development: extrapolating basic biology to stem cell research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952929/ https://www.ncbi.nlm.nih.gov/pubmed/36830851 http://dx.doi.org/10.3390/biomedicines11020310 |
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