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Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset

Behçet disease (BD) is a multisystemic disease that commonly involves the eyes. Although it affects patients in all age groups, data on ocular disease by age of onset are limited. This retrospective, multicenter study aimed to compare epidemiology, systemic and ocular manifestations, treatments and...

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Detalles Bibliográficos
Autores principales: Ostrovsky, Michael, Rosenblatt, Amir, Iriqat, Salam, Shteiwi, Abdallah, Sharon, Yael, Kramer, Michal, Vishnevskia-Dai, Vicktoria, Sar, Shaul, Boulos, Yosif, Tomkins-Netzer, Oren, Lavee, Natalie, Ben-Arie-Weintrob, Yael, Pizem, Hadas, Hareuveni-Blum, Tamar, Schneck, Marina, Gepstein, Raz, Masarwa, Dua, Nakhoul, Nakhoul, Bakshi, Erez, Shulman, Shiri, Goldstein, Michaella, Ramon, Dan, Anouk, Marina, Habot-Wilner, Zohar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952940/
https://www.ncbi.nlm.nih.gov/pubmed/36831160
http://dx.doi.org/10.3390/biomedicines11020624
Descripción
Sumario:Behçet disease (BD) is a multisystemic disease that commonly involves the eyes. Although it affects patients in all age groups, data on ocular disease by age of onset are limited. This retrospective, multicenter study aimed to compare epidemiology, systemic and ocular manifestations, treatments and outcomes between three age groups: juvenile (<18 years), adult (18–39 years) and late (≥40 years) disease onset. The study included 175 ocular BD patients (303 eyes) from Israel and Palestine: juvenile-onset (n = 25, 14.3%), adult-onset (n = 120, 68.6%) and late-onset (n = 30, 17.1%). Most patients in all groups were male. Systemic manifestations were similar in all groups. Systemic co-morbidities were more common in late-onset patients. Bilateral panuveitis was the most common ocular manifestation in all patients. Non-occlusive retinal vasculitis, peripheral vessel occlusions, cataract and elevated intraocular pressure were found more commonly among juvenile-onset eyes. Anterior uveitis and macular ischemia were most common among late-onset eyes, while branch retinal vein occlusion was most common in adult and late-onset eyes. All patients were treated with corticosteroids. Methotrexate, immunomodulatory combinations and biologic treatments were more commonly used for juvenile-onset patients. All groups had a similar visual outcome. Our study showed that patients with ocular BD have varied ocular manifestations and require different treatments according to age of disease onset, but visual outcome is similar.