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Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset

Behçet disease (BD) is a multisystemic disease that commonly involves the eyes. Although it affects patients in all age groups, data on ocular disease by age of onset are limited. This retrospective, multicenter study aimed to compare epidemiology, systemic and ocular manifestations, treatments and...

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Autores principales: Ostrovsky, Michael, Rosenblatt, Amir, Iriqat, Salam, Shteiwi, Abdallah, Sharon, Yael, Kramer, Michal, Vishnevskia-Dai, Vicktoria, Sar, Shaul, Boulos, Yosif, Tomkins-Netzer, Oren, Lavee, Natalie, Ben-Arie-Weintrob, Yael, Pizem, Hadas, Hareuveni-Blum, Tamar, Schneck, Marina, Gepstein, Raz, Masarwa, Dua, Nakhoul, Nakhoul, Bakshi, Erez, Shulman, Shiri, Goldstein, Michaella, Ramon, Dan, Anouk, Marina, Habot-Wilner, Zohar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952940/
https://www.ncbi.nlm.nih.gov/pubmed/36831160
http://dx.doi.org/10.3390/biomedicines11020624
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author Ostrovsky, Michael
Rosenblatt, Amir
Iriqat, Salam
Shteiwi, Abdallah
Sharon, Yael
Kramer, Michal
Vishnevskia-Dai, Vicktoria
Sar, Shaul
Boulos, Yosif
Tomkins-Netzer, Oren
Lavee, Natalie
Ben-Arie-Weintrob, Yael
Pizem, Hadas
Hareuveni-Blum, Tamar
Schneck, Marina
Gepstein, Raz
Masarwa, Dua
Nakhoul, Nakhoul
Bakshi, Erez
Shulman, Shiri
Goldstein, Michaella
Ramon, Dan
Anouk, Marina
Habot-Wilner, Zohar
author_facet Ostrovsky, Michael
Rosenblatt, Amir
Iriqat, Salam
Shteiwi, Abdallah
Sharon, Yael
Kramer, Michal
Vishnevskia-Dai, Vicktoria
Sar, Shaul
Boulos, Yosif
Tomkins-Netzer, Oren
Lavee, Natalie
Ben-Arie-Weintrob, Yael
Pizem, Hadas
Hareuveni-Blum, Tamar
Schneck, Marina
Gepstein, Raz
Masarwa, Dua
Nakhoul, Nakhoul
Bakshi, Erez
Shulman, Shiri
Goldstein, Michaella
Ramon, Dan
Anouk, Marina
Habot-Wilner, Zohar
author_sort Ostrovsky, Michael
collection PubMed
description Behçet disease (BD) is a multisystemic disease that commonly involves the eyes. Although it affects patients in all age groups, data on ocular disease by age of onset are limited. This retrospective, multicenter study aimed to compare epidemiology, systemic and ocular manifestations, treatments and outcomes between three age groups: juvenile (<18 years), adult (18–39 years) and late (≥40 years) disease onset. The study included 175 ocular BD patients (303 eyes) from Israel and Palestine: juvenile-onset (n = 25, 14.3%), adult-onset (n = 120, 68.6%) and late-onset (n = 30, 17.1%). Most patients in all groups were male. Systemic manifestations were similar in all groups. Systemic co-morbidities were more common in late-onset patients. Bilateral panuveitis was the most common ocular manifestation in all patients. Non-occlusive retinal vasculitis, peripheral vessel occlusions, cataract and elevated intraocular pressure were found more commonly among juvenile-onset eyes. Anterior uveitis and macular ischemia were most common among late-onset eyes, while branch retinal vein occlusion was most common in adult and late-onset eyes. All patients were treated with corticosteroids. Methotrexate, immunomodulatory combinations and biologic treatments were more commonly used for juvenile-onset patients. All groups had a similar visual outcome. Our study showed that patients with ocular BD have varied ocular manifestations and require different treatments according to age of disease onset, but visual outcome is similar.
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spelling pubmed-99529402023-02-25 Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset Ostrovsky, Michael Rosenblatt, Amir Iriqat, Salam Shteiwi, Abdallah Sharon, Yael Kramer, Michal Vishnevskia-Dai, Vicktoria Sar, Shaul Boulos, Yosif Tomkins-Netzer, Oren Lavee, Natalie Ben-Arie-Weintrob, Yael Pizem, Hadas Hareuveni-Blum, Tamar Schneck, Marina Gepstein, Raz Masarwa, Dua Nakhoul, Nakhoul Bakshi, Erez Shulman, Shiri Goldstein, Michaella Ramon, Dan Anouk, Marina Habot-Wilner, Zohar Biomedicines Article Behçet disease (BD) is a multisystemic disease that commonly involves the eyes. Although it affects patients in all age groups, data on ocular disease by age of onset are limited. This retrospective, multicenter study aimed to compare epidemiology, systemic and ocular manifestations, treatments and outcomes between three age groups: juvenile (<18 years), adult (18–39 years) and late (≥40 years) disease onset. The study included 175 ocular BD patients (303 eyes) from Israel and Palestine: juvenile-onset (n = 25, 14.3%), adult-onset (n = 120, 68.6%) and late-onset (n = 30, 17.1%). Most patients in all groups were male. Systemic manifestations were similar in all groups. Systemic co-morbidities were more common in late-onset patients. Bilateral panuveitis was the most common ocular manifestation in all patients. Non-occlusive retinal vasculitis, peripheral vessel occlusions, cataract and elevated intraocular pressure were found more commonly among juvenile-onset eyes. Anterior uveitis and macular ischemia were most common among late-onset eyes, while branch retinal vein occlusion was most common in adult and late-onset eyes. All patients were treated with corticosteroids. Methotrexate, immunomodulatory combinations and biologic treatments were more commonly used for juvenile-onset patients. All groups had a similar visual outcome. Our study showed that patients with ocular BD have varied ocular manifestations and require different treatments according to age of disease onset, but visual outcome is similar. MDPI 2023-02-19 /pmc/articles/PMC9952940/ /pubmed/36831160 http://dx.doi.org/10.3390/biomedicines11020624 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ostrovsky, Michael
Rosenblatt, Amir
Iriqat, Salam
Shteiwi, Abdallah
Sharon, Yael
Kramer, Michal
Vishnevskia-Dai, Vicktoria
Sar, Shaul
Boulos, Yosif
Tomkins-Netzer, Oren
Lavee, Natalie
Ben-Arie-Weintrob, Yael
Pizem, Hadas
Hareuveni-Blum, Tamar
Schneck, Marina
Gepstein, Raz
Masarwa, Dua
Nakhoul, Nakhoul
Bakshi, Erez
Shulman, Shiri
Goldstein, Michaella
Ramon, Dan
Anouk, Marina
Habot-Wilner, Zohar
Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset
title Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset
title_full Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset
title_fullStr Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset
title_full_unstemmed Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset
title_short Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset
title_sort ocular behçet disease—clinical manifestations, treatments and outcomes according to age at disease onset
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952940/
https://www.ncbi.nlm.nih.gov/pubmed/36831160
http://dx.doi.org/10.3390/biomedicines11020624
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