Mechanistic Analysis of CCP1 in Generating ΔC2 α-Tubulin in Mammalian Cells and Photoreceptor Neurons

An important post-translational modification (PTM) of α-tubulin is the removal of amino acids from its C-terminus. Removal of the C-terminal tyrosine residue yields detyrosinated α-tubulin, and subsequent removal of the penultimate glutamate residue produces ΔC2-α-tubulin. These PTMs alter the abili...

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Detalles Bibliográficos
Autores principales: Hotta, Takashi, Plemmons, Alexandra, Gebbie, Margo, Ziehm, Trevor A., Blasius, Teresa Lynne, Johnson, Craig, Verhey, Kristen J., Pearring, Jillian N., Ohi, Ryoma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952995/
https://www.ncbi.nlm.nih.gov/pubmed/36830726
http://dx.doi.org/10.3390/biom13020357

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