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The Actin Network Interfacing Diverse Integrin-Mediated Adhesions

The interface between the cellular actin network and diverse forms of integrin-mediated cell adhesions displays a unique capacity to serve as accurate chemical and mechanical sensors of the cell’s microenvironment. Focal adhesion-like structures of diverse cell types, podosomes in osteoclasts, and i...

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Autores principales: Geiger, Benjamin, Boujemaa-Paterski, Rajaa, Winograd-Katz, Sabina E., Balan Venghateri, Jubina, Chung, Wen-Lu, Medalia, Ohad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953007/
https://www.ncbi.nlm.nih.gov/pubmed/36830665
http://dx.doi.org/10.3390/biom13020294
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author Geiger, Benjamin
Boujemaa-Paterski, Rajaa
Winograd-Katz, Sabina E.
Balan Venghateri, Jubina
Chung, Wen-Lu
Medalia, Ohad
author_facet Geiger, Benjamin
Boujemaa-Paterski, Rajaa
Winograd-Katz, Sabina E.
Balan Venghateri, Jubina
Chung, Wen-Lu
Medalia, Ohad
author_sort Geiger, Benjamin
collection PubMed
description The interface between the cellular actin network and diverse forms of integrin-mediated cell adhesions displays a unique capacity to serve as accurate chemical and mechanical sensors of the cell’s microenvironment. Focal adhesion-like structures of diverse cell types, podosomes in osteoclasts, and invadopodia of invading cancer cells display distinct morphologies and apparent functions. Yet, all three share a similar composition and mode of coupling between a protrusive structure (the lamellipodium, the core actin bundle of the podosome, and the invadopodia protrusion, respectively), and a nearby adhesion site. Cytoskeletal or external forces, applied to the adhesion sites, trigger a cascade of unfolding and activation of key adhesome components (e.g., talin, vinculin, integrin), which in turn, trigger the assembly of adhesion sites and generation of adhesion-mediated signals that affect cell behavior and fate. The structural and molecular mechanisms underlying the dynamic crosstalk between the actin cytoskeleton and the adhesome network are discussed.
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spelling pubmed-99530072023-02-25 The Actin Network Interfacing Diverse Integrin-Mediated Adhesions Geiger, Benjamin Boujemaa-Paterski, Rajaa Winograd-Katz, Sabina E. Balan Venghateri, Jubina Chung, Wen-Lu Medalia, Ohad Biomolecules Review The interface between the cellular actin network and diverse forms of integrin-mediated cell adhesions displays a unique capacity to serve as accurate chemical and mechanical sensors of the cell’s microenvironment. Focal adhesion-like structures of diverse cell types, podosomes in osteoclasts, and invadopodia of invading cancer cells display distinct morphologies and apparent functions. Yet, all three share a similar composition and mode of coupling between a protrusive structure (the lamellipodium, the core actin bundle of the podosome, and the invadopodia protrusion, respectively), and a nearby adhesion site. Cytoskeletal or external forces, applied to the adhesion sites, trigger a cascade of unfolding and activation of key adhesome components (e.g., talin, vinculin, integrin), which in turn, trigger the assembly of adhesion sites and generation of adhesion-mediated signals that affect cell behavior and fate. The structural and molecular mechanisms underlying the dynamic crosstalk between the actin cytoskeleton and the adhesome network are discussed. MDPI 2023-02-04 /pmc/articles/PMC9953007/ /pubmed/36830665 http://dx.doi.org/10.3390/biom13020294 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Geiger, Benjamin
Boujemaa-Paterski, Rajaa
Winograd-Katz, Sabina E.
Balan Venghateri, Jubina
Chung, Wen-Lu
Medalia, Ohad
The Actin Network Interfacing Diverse Integrin-Mediated Adhesions
title The Actin Network Interfacing Diverse Integrin-Mediated Adhesions
title_full The Actin Network Interfacing Diverse Integrin-Mediated Adhesions
title_fullStr The Actin Network Interfacing Diverse Integrin-Mediated Adhesions
title_full_unstemmed The Actin Network Interfacing Diverse Integrin-Mediated Adhesions
title_short The Actin Network Interfacing Diverse Integrin-Mediated Adhesions
title_sort actin network interfacing diverse integrin-mediated adhesions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953007/
https://www.ncbi.nlm.nih.gov/pubmed/36830665
http://dx.doi.org/10.3390/biom13020294
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