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The Actin Network Interfacing Diverse Integrin-Mediated Adhesions
The interface between the cellular actin network and diverse forms of integrin-mediated cell adhesions displays a unique capacity to serve as accurate chemical and mechanical sensors of the cell’s microenvironment. Focal adhesion-like structures of diverse cell types, podosomes in osteoclasts, and i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953007/ https://www.ncbi.nlm.nih.gov/pubmed/36830665 http://dx.doi.org/10.3390/biom13020294 |
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author | Geiger, Benjamin Boujemaa-Paterski, Rajaa Winograd-Katz, Sabina E. Balan Venghateri, Jubina Chung, Wen-Lu Medalia, Ohad |
author_facet | Geiger, Benjamin Boujemaa-Paterski, Rajaa Winograd-Katz, Sabina E. Balan Venghateri, Jubina Chung, Wen-Lu Medalia, Ohad |
author_sort | Geiger, Benjamin |
collection | PubMed |
description | The interface between the cellular actin network and diverse forms of integrin-mediated cell adhesions displays a unique capacity to serve as accurate chemical and mechanical sensors of the cell’s microenvironment. Focal adhesion-like structures of diverse cell types, podosomes in osteoclasts, and invadopodia of invading cancer cells display distinct morphologies and apparent functions. Yet, all three share a similar composition and mode of coupling between a protrusive structure (the lamellipodium, the core actin bundle of the podosome, and the invadopodia protrusion, respectively), and a nearby adhesion site. Cytoskeletal or external forces, applied to the adhesion sites, trigger a cascade of unfolding and activation of key adhesome components (e.g., talin, vinculin, integrin), which in turn, trigger the assembly of adhesion sites and generation of adhesion-mediated signals that affect cell behavior and fate. The structural and molecular mechanisms underlying the dynamic crosstalk between the actin cytoskeleton and the adhesome network are discussed. |
format | Online Article Text |
id | pubmed-9953007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99530072023-02-25 The Actin Network Interfacing Diverse Integrin-Mediated Adhesions Geiger, Benjamin Boujemaa-Paterski, Rajaa Winograd-Katz, Sabina E. Balan Venghateri, Jubina Chung, Wen-Lu Medalia, Ohad Biomolecules Review The interface between the cellular actin network and diverse forms of integrin-mediated cell adhesions displays a unique capacity to serve as accurate chemical and mechanical sensors of the cell’s microenvironment. Focal adhesion-like structures of diverse cell types, podosomes in osteoclasts, and invadopodia of invading cancer cells display distinct morphologies and apparent functions. Yet, all three share a similar composition and mode of coupling between a protrusive structure (the lamellipodium, the core actin bundle of the podosome, and the invadopodia protrusion, respectively), and a nearby adhesion site. Cytoskeletal or external forces, applied to the adhesion sites, trigger a cascade of unfolding and activation of key adhesome components (e.g., talin, vinculin, integrin), which in turn, trigger the assembly of adhesion sites and generation of adhesion-mediated signals that affect cell behavior and fate. The structural and molecular mechanisms underlying the dynamic crosstalk between the actin cytoskeleton and the adhesome network are discussed. MDPI 2023-02-04 /pmc/articles/PMC9953007/ /pubmed/36830665 http://dx.doi.org/10.3390/biom13020294 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Geiger, Benjamin Boujemaa-Paterski, Rajaa Winograd-Katz, Sabina E. Balan Venghateri, Jubina Chung, Wen-Lu Medalia, Ohad The Actin Network Interfacing Diverse Integrin-Mediated Adhesions |
title | The Actin Network Interfacing Diverse Integrin-Mediated Adhesions |
title_full | The Actin Network Interfacing Diverse Integrin-Mediated Adhesions |
title_fullStr | The Actin Network Interfacing Diverse Integrin-Mediated Adhesions |
title_full_unstemmed | The Actin Network Interfacing Diverse Integrin-Mediated Adhesions |
title_short | The Actin Network Interfacing Diverse Integrin-Mediated Adhesions |
title_sort | actin network interfacing diverse integrin-mediated adhesions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953007/ https://www.ncbi.nlm.nih.gov/pubmed/36830665 http://dx.doi.org/10.3390/biom13020294 |
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