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Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials
Stem cell-based therapies (SCT) to treat neurodegenerative disorders have promise but clinical trials have only recently begun, and results are not expected for several years. While most SCTs largely lead to a symptomatic therapeutic effect by replacing lost cell types, there may also be disease-mod...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953050/ https://www.ncbi.nlm.nih.gov/pubmed/36831041 http://dx.doi.org/10.3390/biomedicines11020505 |
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author | Marsili, Luca Sharma, Jennifer Outeiro, Tiago Fleming Colosimo, Carlo |
author_facet | Marsili, Luca Sharma, Jennifer Outeiro, Tiago Fleming Colosimo, Carlo |
author_sort | Marsili, Luca |
collection | PubMed |
description | Stem cell-based therapies (SCT) to treat neurodegenerative disorders have promise but clinical trials have only recently begun, and results are not expected for several years. While most SCTs largely lead to a symptomatic therapeutic effect by replacing lost cell types, there may also be disease-modifying therapeutic effects. In fact, SCT may complement a multi-drug, subtype-specific therapeutic approach, consistent with the idea of precision medicine, which matches molecular therapies to biological subtypes of disease. In this narrative review, we examine published and ongoing trials in SCT in Parkinson’s Disease, atypical parkinsonian disorders, Huntington’s disease, amyotrophic lateral sclerosis, and spinocerebellar ataxia in humans. We discuss the benefits and pitfalls of using this treatment approach within the spectrum of disease-modification efforts in neurodegenerative diseases. SCT may hold greater promise in the treatment of neurodegenerative disorders, but much research is required to determine the feasibility, safety, and efficacy of these complementary aims of therapeutic efforts. |
format | Online Article Text |
id | pubmed-9953050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99530502023-02-25 Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials Marsili, Luca Sharma, Jennifer Outeiro, Tiago Fleming Colosimo, Carlo Biomedicines Review Stem cell-based therapies (SCT) to treat neurodegenerative disorders have promise but clinical trials have only recently begun, and results are not expected for several years. While most SCTs largely lead to a symptomatic therapeutic effect by replacing lost cell types, there may also be disease-modifying therapeutic effects. In fact, SCT may complement a multi-drug, subtype-specific therapeutic approach, consistent with the idea of precision medicine, which matches molecular therapies to biological subtypes of disease. In this narrative review, we examine published and ongoing trials in SCT in Parkinson’s Disease, atypical parkinsonian disorders, Huntington’s disease, amyotrophic lateral sclerosis, and spinocerebellar ataxia in humans. We discuss the benefits and pitfalls of using this treatment approach within the spectrum of disease-modification efforts in neurodegenerative diseases. SCT may hold greater promise in the treatment of neurodegenerative disorders, but much research is required to determine the feasibility, safety, and efficacy of these complementary aims of therapeutic efforts. MDPI 2023-02-09 /pmc/articles/PMC9953050/ /pubmed/36831041 http://dx.doi.org/10.3390/biomedicines11020505 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Marsili, Luca Sharma, Jennifer Outeiro, Tiago Fleming Colosimo, Carlo Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials |
title | Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials |
title_full | Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials |
title_fullStr | Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials |
title_full_unstemmed | Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials |
title_short | Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials |
title_sort | stem cell therapies in movement disorders: lessons from clinical trials |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953050/ https://www.ncbi.nlm.nih.gov/pubmed/36831041 http://dx.doi.org/10.3390/biomedicines11020505 |
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