Gene Therapy with p14/tBID Induces Selective and Synergistic Apoptosis in Mutant Ras and Mutant p53 Cancer Cells In Vitro and In Vivo

Any gene therapy for cancer will be predicated upon its selectivity against cancer cells and non-toxicity to normal cells. Therefore, safeguards are needed to prevent its activation in normal cells. We designed a minimal p14(ARF) promoter with upstream Ap1 and E2F enhancer elements and a downstream...

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Detalles Bibliográficos
Autores principales: Fine, Robert L., Mao, Yuehua, Garcia-Carracedo, Dario, Su, Gloria H., Qiu, Wanglong, Hochfeld, Uri, Nichols, Gwen, Li, Yong-Liang, Dinnen, Richard D., Raffo, Anthony, Brandt-Rauf, Paul W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953161/
https://www.ncbi.nlm.nih.gov/pubmed/36830797
http://dx.doi.org/10.3390/biomedicines11020258

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