Lower Extremity Arterial Disease in Type 2 Diabetes Mellitus: Metformin Inhibits Femoral Artery Ultrastructural Alterations as well as Vascular Tissue Levels of AGEs/ET-1 Axis-Mediated Inflammation and Modulation of Vascular iNOS and eNOS Expression

Lower extremity arterial disease (LEAD) is a major risk factor for amputation in diabetic patients. The advanced glycation end products (AGEs)/endothelin-1 (ET-1)/nitric oxide synthase (NOS) axis-mediated femoral artery injury with and without metformin has not been previously investigated. Type 2 d...

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Detalles Bibliográficos
Autores principales: Shati, Ayed A., Maarouf, Amro, Dawood, Amal F., Bayoumy, Nervana M., Alqahtani, Youssef A., A. Eid, Refaat, Alqahtani, Saeed M., Abd Ellatif, Mohamed, Al-Ani, Bahjat, Albawardi, Alia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953164/
https://www.ncbi.nlm.nih.gov/pubmed/36830898
http://dx.doi.org/10.3390/biomedicines11020361

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