Cargando…

Hyperactivation of p21-Activated Kinases in Human Cancer and Therapeutic Sensitivity

Over the last three decades, p21-activated kinases (PAKs) have emerged as prominent intracellular nodular signaling molecules in cancer cells with a spectrum of cancer-promoting functions ranging from cell survival to anchorage-independent growth to cellular invasiveness. As PAK family members are w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sankaran, Deivendran, Amjesh, Revikumar, Paul, Aswathy Mary, George, Bijesh, Kala, Rajat, Saini, Sunil, Kumar, Rakesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953343/ https://www.ncbi.nlm.nih.gov/pubmed/36830998 http://dx.doi.org/10.3390/biomedicines11020462

Ejemplares similares

The Revelation of Continuously Organized, Co-Overexpressed Protein-Coding Genes with Roles in Cellular Communications in Breast Cancer
por: Paul, Aswathy Mary, et al.
Publicado: (2022)

Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells
por: George, Bijesh, et al.
Publicado: (2021)

Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics
por: George, Bijesh, et al.
Publicado: (2021)

Delineation of Pathogenomic Insights of Breast Cancer in Young Women
por: Paul, Aswathy Mary, et al.
Publicado: (2022)

Structure based virtual screening of inhibitors for binding at the allosteric site of HCV RNA dependent RNA polymerase
por: Revikumar, Amjesh, et al.
Publicado: (2012)

AKT1 Transcriptomic Landscape in Breast Cancer Cells
por: George, Bijesh, et al.
Publicado: (2022)

Protein kinases regulate hyperactivated motility of human sperm
por: Wang, Ya-Yan, et al.
Publicado: (2021)

Cyclophilin A Impairs Efferocytosis and Accelerates Atherosclerosis by Overexpressing CD 47 and Down-Regulating Calreticulin
por: Anandan, Vinitha, et al.
Publicado: (2021)

p21-activated kinase signaling in breast cancer
por: Gururaj, Anupama E, et al.
Publicado: (2005)

Hyperactivating p53 in Human Papillomavirus-Driven Cancers: A Potential Therapeutic Intervention
por: Idres, Yusuf M., et al.
Publicado: (2022)

Hyperactivated endolysosomal trafficking in melanoma
por: Alonso-Curbelo, Direna, et al.
Publicado: (2015)

The Agrobacterium VirD5 protein hyperactivates the mitotic Aurora kinase in host cells
por: Zhang, Xiaorong, et al.
Publicado: (2019)

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation
por: Ricke, Robin M., et al.
Publicado: (2011)

Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation
por: Kuettel, Sabine, et al.
Publicado: (2011)

Mitochondrial Hyperactivation and Enhanced ROS Production are Involved in Toxicity Induced by Oncogenic Kinases Over-Signaling
por: Ceccon, Monica, et al.
Publicado: (2018)

The mechanics of hyperactivation in adhered human sperm
por: Ooi, E. H, et al.
Publicado: (2014)

Flagellar hyperactivation of bull and boar spermatozoa
por: Harayama, Hiroshi
Publicado: (2018)

Enhancement of rat spermatozoal hyperactivation by progesterone
por: MIYAZAWA, Yuki, et al.
Publicado: (2023)

Hyperactivation of P21(ras) and the Hematopoietic-Specific Rho Gtpase, Rac2, Cooperate to Alter the Proliferation of Neurofibromin-Deficient Mast Cells in Vivo and in Vitro
por: Ingram, David A., et al.
Publicado: (2001)

Serotonergic signals enhanced hamster sperm hyperactivation
por: SAKAMOTO, Chiyori, et al.
Publicado: (2021)

Signalling by senescent melanocytes hyperactivates hair growth
por: Wang, Xiaojie, et al.
Publicado: (2023)

The Triple-Negative Breast Cancer Database: an omics platform for reference, integration and analysis of triple-negative breast cancer data
por: Raju, Rajesh, et al.
Publicado: (2014)

Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands
por: Wang, Rui-An, et al.
Publicado: (2003)

Estrogen suppresses melatonin-enhanced hyperactivation of hamster spermatozoa
por: FUJINOKI, Masakatsu, et al.
Publicado: (2015)

Platelets and COVID-19: Inflammation, Hyperactivation and Additional Questions
por: Koupenova, Milka, et al.
Publicado: (2020)

Eugenol-hyperactivated nymphs of Triatoma infestans become intoxicated faster than non-hyperactivated nymphs when exposed to a permethrin-treated surface
por: Reynoso, Mercedes María Noel, et al.
Publicado: (2018)

p300 Influences Butyrate-Mediated WNT Hyperactivation In Colorectal Cancer Cells
por: Lazarova, Darina L, et al.
Publicado: (2013)

EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity
por: Berg, Johannes Lorenz, et al.
Publicado: (2021)

Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells
por: Parvathy, Muraleedharan, et al.
Publicado: (2016)

Serine/Threonine Kinase 17A Is a Novel Candidate for Therapeutic Targeting in Glioblastoma
por: Mao, Pingping, et al.
Publicado: (2013)

Dysregulated Interferon Response and Immune Hyperactivation in Severe COVID-19: Targeting STATs as a Novel Therapeutic Strategy
por: Eskandarian Boroujeni, Mahdi, et al.
Publicado: (2022)

Metastasis-associated protein 1 is an upstream regulator of DNMT3a and stimulator of insulin-growth factor binding protein-3 in breast cancer
por: Deivendran, S., et al.
Publicado: (2017)

Dysfunctional GABAergic inhibition in the prefrontal cortex leading to "psychotic" hyperactivation
por: Tanaka, Shoji
Publicado: (2008)

Behavioral Mechanism during Human Sperm Chemotaxis: Involvement of Hyperactivation
por: Armon, Leah, et al.
Publicado: (2011)

Hyperactivation of the habenula as a link between depression and sleep disturbance
por: Aizawa, Hidenori, et al.
Publicado: (2013)

Greatwall promotes cell transformation by hyperactivating AKT in human malignancies
por: Vera, Jorge, et al.
Publicado: (2015)

Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice
por: SUGIYAMA, Yukiko, et al.
Publicado: (2019)

Hyperactivation of Sympathetic Nerves Drives Melanocyte Stem Cell Depletion
por: Zhang, Bing, et al.
Publicado: (2020)

Severe COVID-19 is associated with hyperactivation of the alternative complement pathway
por: Boussier, Jeremy, et al.
Publicado: (2022)

Molecular mechanism of hyperactivation conferred by a truncation of TRPA1
por: Bali, Avnika, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pt4gb43o45640slgbqi1fb6ics