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Regulation of the Epithelial to Mesenchymal Transition in Osteosarcoma

The epithelial to mesenchymal transition (EMT) is a cellular process that has been linked to the promotion of aggressive cellular features in many cancer types. It is characterized by the loss of the epithelial cell phenotype and a shift to a more mesenchymal phenotype and is accompanied by an assoc...

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Detalles Bibliográficos
Autores principales: Hinton, Kristin, Kirk, Andrew, Paul, Paulose, Persad, Sujata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953423/
https://www.ncbi.nlm.nih.gov/pubmed/36830767
http://dx.doi.org/10.3390/biom13020398
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author Hinton, Kristin
Kirk, Andrew
Paul, Paulose
Persad, Sujata
author_facet Hinton, Kristin
Kirk, Andrew
Paul, Paulose
Persad, Sujata
author_sort Hinton, Kristin
collection PubMed
description The epithelial to mesenchymal transition (EMT) is a cellular process that has been linked to the promotion of aggressive cellular features in many cancer types. It is characterized by the loss of the epithelial cell phenotype and a shift to a more mesenchymal phenotype and is accompanied by an associated change in cell markers. EMT is highly complex and regulated via multiple signaling pathways. While the importance of EMT is classically described for carcinomas—cancers of epithelial origin—it has also been clearly demonstrated in non-epithelial cancers, including osteosarcoma (OS), a primary bone cancer predominantly affecting children and young adults. Recent studies examining EMT in OS have highlighted regulatory roles for multiple proteins, non-coding nucleic acids, and components of the tumor micro-environment. This review serves to summarize these experimental findings, identify key families of regulatory molecules, and identify potential therapeutic targets specific to the EMT process in OS.
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spelling pubmed-99534232023-02-25 Regulation of the Epithelial to Mesenchymal Transition in Osteosarcoma Hinton, Kristin Kirk, Andrew Paul, Paulose Persad, Sujata Biomolecules Review The epithelial to mesenchymal transition (EMT) is a cellular process that has been linked to the promotion of aggressive cellular features in many cancer types. It is characterized by the loss of the epithelial cell phenotype and a shift to a more mesenchymal phenotype and is accompanied by an associated change in cell markers. EMT is highly complex and regulated via multiple signaling pathways. While the importance of EMT is classically described for carcinomas—cancers of epithelial origin—it has also been clearly demonstrated in non-epithelial cancers, including osteosarcoma (OS), a primary bone cancer predominantly affecting children and young adults. Recent studies examining EMT in OS have highlighted regulatory roles for multiple proteins, non-coding nucleic acids, and components of the tumor micro-environment. This review serves to summarize these experimental findings, identify key families of regulatory molecules, and identify potential therapeutic targets specific to the EMT process in OS. MDPI 2023-02-20 /pmc/articles/PMC9953423/ /pubmed/36830767 http://dx.doi.org/10.3390/biom13020398 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hinton, Kristin
Kirk, Andrew
Paul, Paulose
Persad, Sujata
Regulation of the Epithelial to Mesenchymal Transition in Osteosarcoma
title Regulation of the Epithelial to Mesenchymal Transition in Osteosarcoma
title_full Regulation of the Epithelial to Mesenchymal Transition in Osteosarcoma
title_fullStr Regulation of the Epithelial to Mesenchymal Transition in Osteosarcoma
title_full_unstemmed Regulation of the Epithelial to Mesenchymal Transition in Osteosarcoma
title_short Regulation of the Epithelial to Mesenchymal Transition in Osteosarcoma
title_sort regulation of the epithelial to mesenchymal transition in osteosarcoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953423/
https://www.ncbi.nlm.nih.gov/pubmed/36830767
http://dx.doi.org/10.3390/biom13020398
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