Comparison among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression

Neuroblastoma (NB) is the most common extracranial tumor of early childhood and accounts for 15% of all pediatric cancer mortalities. However, the precise pathways and genes underlying its progression are unknown. Therefore, we performed a differential gene expression analysis of neuroblastoma stage...

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Autores principales: Cagnin, Stefano, Knedlik, Tomas, Vianello, Caterina, Magalhães Rebelo, Ana Paula, De Mario, Agnese, Giacomello, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953471/
https://www.ncbi.nlm.nih.gov/pubmed/36831133
http://dx.doi.org/10.3390/biomedicines11020596
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author Cagnin, Stefano
Knedlik, Tomas
Vianello, Caterina
Magalhães Rebelo, Ana Paula
De Mario, Agnese
Giacomello, Marta
author_facet Cagnin, Stefano
Knedlik, Tomas
Vianello, Caterina
Magalhães Rebelo, Ana Paula
De Mario, Agnese
Giacomello, Marta
author_sort Cagnin, Stefano
collection PubMed
description Neuroblastoma (NB) is the most common extracranial tumor of early childhood and accounts for 15% of all pediatric cancer mortalities. However, the precise pathways and genes underlying its progression are unknown. Therefore, we performed a differential gene expression analysis of neuroblastoma stage 1 and stage 4 + 4S to discover biological processes associated with NB progression. From this preliminary analysis, we found that NB samples (stage 4 + 4S) are characterized by altered expression of some proteins involved in mitochondria function and mitochondria–ER contact sites (MERCS). Although further analyses remain necessary, this review may provide new hints to better understand NB molecular etiopathogenesis, by suggesting that MERCS alterations could be involved in the progression of NB.
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spelling pubmed-99534712023-02-25 Comparison among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression Cagnin, Stefano Knedlik, Tomas Vianello, Caterina Magalhães Rebelo, Ana Paula De Mario, Agnese Giacomello, Marta Biomedicines Brief Report Neuroblastoma (NB) is the most common extracranial tumor of early childhood and accounts for 15% of all pediatric cancer mortalities. However, the precise pathways and genes underlying its progression are unknown. Therefore, we performed a differential gene expression analysis of neuroblastoma stage 1 and stage 4 + 4S to discover biological processes associated with NB progression. From this preliminary analysis, we found that NB samples (stage 4 + 4S) are characterized by altered expression of some proteins involved in mitochondria function and mitochondria–ER contact sites (MERCS). Although further analyses remain necessary, this review may provide new hints to better understand NB molecular etiopathogenesis, by suggesting that MERCS alterations could be involved in the progression of NB. MDPI 2023-02-17 /pmc/articles/PMC9953471/ /pubmed/36831133 http://dx.doi.org/10.3390/biomedicines11020596 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Cagnin, Stefano
Knedlik, Tomas
Vianello, Caterina
Magalhães Rebelo, Ana Paula
De Mario, Agnese
Giacomello, Marta
Comparison among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression
title Comparison among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression
title_full Comparison among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression
title_fullStr Comparison among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression
title_full_unstemmed Comparison among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression
title_short Comparison among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression
title_sort comparison among neuroblastoma stages suggests the involvement of mitochondria in tumor progression
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953471/
https://www.ncbi.nlm.nih.gov/pubmed/36831133
http://dx.doi.org/10.3390/biomedicines11020596
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