Cargando…

Selective In Vitro and Ex Vivo Staining of Brain Neurofibrillary Tangles and Amyloid Plaques by Novel Ethylene Ethynylene-Based Optical Sensors

The identification of protein aggregates as biomarkers for neurodegeneration is an area of interest for disease diagnosis and treatment development. In this work, we present novel super luminescent conjugated polyelectrolyte molecules as ex vivo sensors for tau-paired helical filaments (PHFs) and am...

Descripción completa

Detalles Bibliográficos
Autores principales:	Monge, Florencia A., Fanni, Adeline M., Donabedian, Patrick L., Hulse, Jonathan, Maphis, Nicole M., Jiang, Shanya, Donaldson, Tia N., Clark, Benjamin J., Whitten, David G., Bhaskar, Kiran, Chi, Eva Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953543/ https://www.ncbi.nlm.nih.gov/pubmed/36831917 http://dx.doi.org/10.3390/bios13020151

Ejemplares similares

Inside Alzheimer brain with CLARITY: senile plaques, neurofibrillary tangles and axons in 3-D
por: Ando, Kunie, et al.
Publicado: (2014)

Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer’s Disease
por: Furcila, Diana, et al.
Publicado: (2019)

Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and APOE in Alzheimer’s Disease
por: Das, Sudeshna, et al.
Publicado: (2023)

Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease
por: Miyashita, A, et al.
Publicado: (2014)

The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease
por: Hondius, David C., et al.
Publicado: (2021)

Aluminum and Tau in Neurofibrillary Tangles in Familial Alzheimer’s Disease
por: Mold, Matthew John, et al.
Publicado: (2021)

Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer’s disease patients
por: Michael, Ralph, et al.
Publicado: (2017)

Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease
por: Bryan, Kathryn J, et al.
Publicado: (2008)

Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer’s disease
por: Wang, Chunyu, et al.
Publicado: (2016)

In vivo quantification of neurofibrillary tangles with [(18)F]MK-6240
por: Pascoal, Tharick A., et al.
Publicado: (2018)

Clinical Neuropathology image 5-2016: neurofibrillary tangle-rich ganglioglioma
por: Gelpi, Ellen, et al.
Publicado: (2016)

Braak neurofibrillary tangle staging prediction from in vivo MRI metrics
por: Dallaire-Théroux, Caroline, et al.
Publicado: (2019)

Association of Neighborhood-Level Disadvantage With Neurofibrillary Tangles on Neuropathological Tissue Assessment
por: Powell, W. Ryan, et al.
Publicado: (2022)

Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles
por: Dregni, Aurelio J., et al.
Publicado: (2022)

Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles
por: Hunter, Sally, et al.
Publicado: (2015)

Phosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles
por: Nishikawa, Tomokazu, et al.
Publicado: (2014)

Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain
por: Cox, Paul Alan, et al.
Publicado: (2016)

Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies
por: Chibnik, Lori B, et al.
Publicado: (2017)

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain
por: Fadul, Motaz M., et al.
Publicado: (2020)

Entorhinal Subfield Vulnerability to Neurofibrillary Tangles in Aging and the Preclinical Stage of Alzheimer’s Disease
por: Llamas-Rodríguez, Josué, et al.
Publicado: (2022)

Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment
por: Marx, Gabriel A., et al.
Publicado: (2022)

Vitamin E therapy prevents the accumulation of congophilic amyloid plaques and neurofibrillary tangles in the hippocampus in a rat model of Alzheimer’s disease
por: Jahanshahi, Mehrdad, et al.
Publicado: (2020)

Highly Selective Tau-SPECT Imaging Probes for Detection of Neurofibrillary Tangles in Alzheimer’s Disease
por: Ono, Masahiro, et al.
Publicado: (2016)

Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer’s Disease and Related Neurological Disorders
por: Mold, Matthew John, et al.
Publicado: (2020)

Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research
por: Moloney, Christina M., et al.
Publicado: (2021)

Neurofibrillary tangles in Alzheimer's disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics
por: Metaxas, Athanasios, et al.
Publicado: (2016)

Altered Regulation of KIAA0566, and Katanin Signaling Expression in the Locus Coeruleus With Neurofibrillary Tangle Pathology
por: Andrés-Benito, Pol, et al.
Publicado: (2018)

Gene Expression of Quaking in Sporadic Alzheimer’s Disease Patients is Both Upregulated and Related to Expression Levels of Genes Involved in Amyloid Plaque and Neurofibrillary Tangle Formation
por: Farnsworth, Bryn, et al.
Publicado: (2016)

Accumulation of neurofibrillary tangles and activated microglia is associated with lower neuron densities in the aphasic variant of Alzheimer’s disease
por: Ohm, Daniel T., et al.
Publicado: (2020)

Use of Zebrafish Genetic Models to Study Etiology of the Amyloid-Beta and Neurofibrillary Tangle Pathways in Alzheimer's Disease
por: Kiper, Keturah, et al.
Publicado: (2022)

Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration
por: Ashton, Nicholas J., et al.
Publicado: (2019)

Image-Guided Development of Heterocyclic Sulfoxides as Ligands for Tau Neurofibrillary Tangles: From First-in-Man to Second-Generation Ligands
por: Rafique, Waqas, et al.
Publicado: (2018)

Human TAU(P301L) overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain
por: Cosacak, Mehmet I., et al.
Publicado: (2017)

Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease
por: Bengoa-Vergniory, Nora, et al.
Publicado: (2021)

CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles
por: Kaeser, Stephan A., et al.
Publicado: (2021)

Phenotypic Displays of Cholinergic Enzymes Associate With Markers of Inflammation, Neurofibrillary Tangles, and Neurodegeneration in Pre- and Early Symptomatic Dementia Subjects
por: Teitsdottir, Unnur D., et al.
Publicado: (2022)

A Histochemical Analysis of Neurofibrillary Tangles in Olfactory Epithelium, a Study Based on an Autopsy Case of Juvenile Alzheimer’s Disease
por: Shimizu, Shino, et al.
Publicado: (2022)

Early amygdala and ERC atrophy linked to 3D reconstruction of rostral neurofibrillary tau tangle pathology in Alzheimer’s disease()
por: Stouffer, Kaitlin M., et al.
Publicado: (2023)

AAV-Tau Mediates Pyramidal Neurodegeneration by Cell-Cycle Re-Entry without Neurofibrillary Tangle Formation in Wild-Type Mice
por: Jaworski, Tomasz, et al.
Publicado: (2009)

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity
por: Ahmed, Zeshan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_q51ghqcl6rni4thor5r3okt0n2