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Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study

Patients after solid organ transplantation (SOT) are more susceptible to various viral infections, including alphaherpesviruses. Therefore, the aim of our study was to investigate the risk of alphaherpesvirus infections, including herpes simplex and herpes zoster, after solid organ transplantation....

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Autores principales: Chuang, Ya-Wen, Huang, Shih-Ting, Wang, I-Kuan, Lo, Ying-Chih, Chang, Chiz-Tzung, Lin, Cheng-Li, Yu, Tung-Min, Li, Chi-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953582/
https://www.ncbi.nlm.nih.gov/pubmed/36831173
http://dx.doi.org/10.3390/biomedicines11020637
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author Chuang, Ya-Wen
Huang, Shih-Ting
Wang, I-Kuan
Lo, Ying-Chih
Chang, Chiz-Tzung
Lin, Cheng-Li
Yu, Tung-Min
Li, Chi-Yuan
author_facet Chuang, Ya-Wen
Huang, Shih-Ting
Wang, I-Kuan
Lo, Ying-Chih
Chang, Chiz-Tzung
Lin, Cheng-Li
Yu, Tung-Min
Li, Chi-Yuan
author_sort Chuang, Ya-Wen
collection PubMed
description Patients after solid organ transplantation (SOT) are more susceptible to various viral infections, including alphaherpesviruses. Therefore, the aim of our study was to investigate the risk of alphaherpesvirus infections, including herpes simplex and herpes zoster, after solid organ transplantation. Inpatient records from the Taiwan National Health Insurance Research Database (NHIRD) defined solid organ recipients, including heart, liver, lung, and kidney, hospitalized for alphaherpesvirus infections as a severe case group of transplants and matched them with a nontransplant cohort. We enrolled 18,064 individuals, of whom 9032 were in each group. A higher risk of severe alphaherpesvirus infection was noted in solid organ recipients (aHR = 9.19; p < 0.001) than in the general population. In addition, solid organ transplant recipients had the highest risk of alphaherpesvirus infection within 1 year after transplantation (aHR = 25.18). The comparison found a higher risk of herpes zoster and herpes simplex infections in recipients of kidney (aHR = 9.13; aHR = 12.13), heart (aHR = 14.34; aHR = 18.54), and liver (aHR = 5.90; aHR = 8.28) transplants. Patients who underwent solid organ transplantation had a significantly higher risk of alphaherpesvirus infection than the general population.
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spelling pubmed-99535822023-02-25 Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study Chuang, Ya-Wen Huang, Shih-Ting Wang, I-Kuan Lo, Ying-Chih Chang, Chiz-Tzung Lin, Cheng-Li Yu, Tung-Min Li, Chi-Yuan Biomedicines Article Patients after solid organ transplantation (SOT) are more susceptible to various viral infections, including alphaherpesviruses. Therefore, the aim of our study was to investigate the risk of alphaherpesvirus infections, including herpes simplex and herpes zoster, after solid organ transplantation. Inpatient records from the Taiwan National Health Insurance Research Database (NHIRD) defined solid organ recipients, including heart, liver, lung, and kidney, hospitalized for alphaherpesvirus infections as a severe case group of transplants and matched them with a nontransplant cohort. We enrolled 18,064 individuals, of whom 9032 were in each group. A higher risk of severe alphaherpesvirus infection was noted in solid organ recipients (aHR = 9.19; p < 0.001) than in the general population. In addition, solid organ transplant recipients had the highest risk of alphaherpesvirus infection within 1 year after transplantation (aHR = 25.18). The comparison found a higher risk of herpes zoster and herpes simplex infections in recipients of kidney (aHR = 9.13; aHR = 12.13), heart (aHR = 14.34; aHR = 18.54), and liver (aHR = 5.90; aHR = 8.28) transplants. Patients who underwent solid organ transplantation had a significantly higher risk of alphaherpesvirus infection than the general population. MDPI 2023-02-20 /pmc/articles/PMC9953582/ /pubmed/36831173 http://dx.doi.org/10.3390/biomedicines11020637 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chuang, Ya-Wen
Huang, Shih-Ting
Wang, I-Kuan
Lo, Ying-Chih
Chang, Chiz-Tzung
Lin, Cheng-Li
Yu, Tung-Min
Li, Chi-Yuan
Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study
title Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study
title_full Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study
title_fullStr Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study
title_full_unstemmed Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study
title_short Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study
title_sort risk of severe alphaherpesvirus infection after solid organ transplantation: a nationwide population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953582/
https://www.ncbi.nlm.nih.gov/pubmed/36831173
http://dx.doi.org/10.3390/biomedicines11020637
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