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Circulating Biomarkers for Prediction of Immunotherapy Response in NSCLC
Non-small cell lung cancer (NSCLC) constitutes the majority of the lung cancer population and the prognosis is poor. In recent years, immunotherapy has become the standard of care for advanced NSCLC patients as numerous trials demonstrated that immune checkpoint inhibitors (ICI) are more efficacious...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953588/ https://www.ncbi.nlm.nih.gov/pubmed/36831044 http://dx.doi.org/10.3390/biomedicines11020508 |
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author | Goh, Kah Yee Cheng, Terence You De Tham, Su Chin Lim, Darren Wan-Teck |
author_facet | Goh, Kah Yee Cheng, Terence You De Tham, Su Chin Lim, Darren Wan-Teck |
author_sort | Goh, Kah Yee |
collection | PubMed |
description | Non-small cell lung cancer (NSCLC) constitutes the majority of the lung cancer population and the prognosis is poor. In recent years, immunotherapy has become the standard of care for advanced NSCLC patients as numerous trials demonstrated that immune checkpoint inhibitors (ICI) are more efficacious than conventional chemotherapy. However, only a minority of NSCLC patients benefit from this treatment. Therefore, there is an unmet need for biomarkers that could accurately predict response to immunotherapy. Liquid biopsy allows repeated sampling of blood-based biomarkers in a non-invasive manner for the dynamic monitoring of treatment response. In this review, we summarize the efforts and progress made in the identification of circulating biomarkers that predict immunotherapy benefit for NSCLC patients. We also discuss the challenges with future implementation of circulating biomarkers into clinical practice. |
format | Online Article Text |
id | pubmed-9953588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99535882023-02-25 Circulating Biomarkers for Prediction of Immunotherapy Response in NSCLC Goh, Kah Yee Cheng, Terence You De Tham, Su Chin Lim, Darren Wan-Teck Biomedicines Review Non-small cell lung cancer (NSCLC) constitutes the majority of the lung cancer population and the prognosis is poor. In recent years, immunotherapy has become the standard of care for advanced NSCLC patients as numerous trials demonstrated that immune checkpoint inhibitors (ICI) are more efficacious than conventional chemotherapy. However, only a minority of NSCLC patients benefit from this treatment. Therefore, there is an unmet need for biomarkers that could accurately predict response to immunotherapy. Liquid biopsy allows repeated sampling of blood-based biomarkers in a non-invasive manner for the dynamic monitoring of treatment response. In this review, we summarize the efforts and progress made in the identification of circulating biomarkers that predict immunotherapy benefit for NSCLC patients. We also discuss the challenges with future implementation of circulating biomarkers into clinical practice. MDPI 2023-02-09 /pmc/articles/PMC9953588/ /pubmed/36831044 http://dx.doi.org/10.3390/biomedicines11020508 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Goh, Kah Yee Cheng, Terence You De Tham, Su Chin Lim, Darren Wan-Teck Circulating Biomarkers for Prediction of Immunotherapy Response in NSCLC |
title | Circulating Biomarkers for Prediction of Immunotherapy Response in NSCLC |
title_full | Circulating Biomarkers for Prediction of Immunotherapy Response in NSCLC |
title_fullStr | Circulating Biomarkers for Prediction of Immunotherapy Response in NSCLC |
title_full_unstemmed | Circulating Biomarkers for Prediction of Immunotherapy Response in NSCLC |
title_short | Circulating Biomarkers for Prediction of Immunotherapy Response in NSCLC |
title_sort | circulating biomarkers for prediction of immunotherapy response in nsclc |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953588/ https://www.ncbi.nlm.nih.gov/pubmed/36831044 http://dx.doi.org/10.3390/biomedicines11020508 |
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